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Authors: Julija Razumiene 1 ; Vidute Gureviciene 1 ; Marius Dagys 1 ; Ieva Sakinyte 1 ; Algimantas Jonuska 1 ; Laurynas Rimsevicius 2 ; Svitlana Marchenko 3 and Alexey Soldatkin 3

Affiliations: 1 Institute of Biochemistry and Vilnius University, Lithuania ; 2 Nephrology Centre and Vilnius University, Lithuania ; 3 Laboratory of Biomolecular Electronics, Institute of Molecular Biology and Genetics and National Academy of Sciences of Ukraine, Ukraine

ISBN: 978-989-758-170-0

Keyword(s): Biosensor, Amperometric Urea Detection, Potentiometric Urea Detection, Urease, Sodium and Potassium Electrodes, Blood Dialysis.

Related Ontology Subjects/Areas/Topics: Biomaterials ; Biomedical Engineering ; Biomedical Equipment ; Biomedical Instrumentation ; Biomedical Instruments and Devices ; Biomedical Sensors ; Devices ; Health Monitoring Devices ; Human-Computer Interaction ; Physiological Computing Systems

Abstract: The idea of developing multi-parameter urea analyser comprising urea, Na+ and K+ selective electrodes has been considered. For this purpose the urea biosensors based on urease and recombinant urease working in amperometric and potentiometric way were developed. The working parameters of both urea biosensors were studied and optimized. Possibilities of real samples analysis using the developed biosensors were shown by measuring urea concentrations in blood dialysate taken from patients with renal failure. Both the potentiometric and the amperometric biosensors demonstrated high degree of signal reproducibility (the relative standard deviation of responses did not exceed 5 %). Change of sodium and potassium concentrations during blood hemodialysis is dangerous life-threatening condition and their monitoring is an important feature of point-of-care analyser. For this purpose high integrity commercial Na+ and K + selective electrodes were analysed and our own signal amplification and proc essing system proposed. (More)

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Paper citation in several formats:
Razumiene, J.; Gureviciene, V.; Dagys, M.; Sakinyte, I.; Jonuska, A.; Rimsevicius, L.; Marchenko, S. and Soldatkin, A. (2016). Development of Multi-parameter Analyser based on Electrochemical Urea Biosensors and Electrolyte Electrodes for Monitoring of Hemodialysis Patients.In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1 BIODEVICES: BIODEVICES, (BIOSTEC 2016) ISBN 978-989-758-170-0, pages 93-101. DOI: 10.5220/0005814100930101

@conference{biodevices16,
author={Julija Razumiene. and Vidute Gureviciene. and Marius Dagys. and Ieva Sakinyte. and Algimantas Jonuska. and Laurynas Rimsevicius. and Svitlana Marchenko. and Alexey Soldatkin.},
title={Development of Multi-parameter Analyser based on Electrochemical Urea Biosensors and Electrolyte Electrodes for Monitoring of Hemodialysis Patients},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1 BIODEVICES: BIODEVICES, (BIOSTEC 2016)},
year={2016},
pages={93-101},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005814100930101},
isbn={978-989-758-170-0},
}

TY - CONF

JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1 BIODEVICES: BIODEVICES, (BIOSTEC 2016)
TI - Development of Multi-parameter Analyser based on Electrochemical Urea Biosensors and Electrolyte Electrodes for Monitoring of Hemodialysis Patients
SN - 978-989-758-170-0
AU - Razumiene, J.
AU - Gureviciene, V.
AU - Dagys, M.
AU - Sakinyte, I.
AU - Jonuska, A.
AU - Rimsevicius, L.
AU - Marchenko, S.
AU - Soldatkin, A.
PY - 2016
SP - 93
EP - 101
DO - 10.5220/0005814100930101

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