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Authors: V. Errico 1 ; R. Molinaro 1 ; C. Gargioli 1 ; F. Ferranti 2 ; M. Dinescu 3 ; S. Cannata 1 ; G. Saggio 1 ; S. Rufini 1 and A. Desideri 1

Affiliations: 1 University of Rome “Tor Vergata”, Italy ; 2 Italian Space Agency, Italy ; 3 National Institute of Plasma Lasers and Radiation, Romania

ISBN: 978-989-758-170-0

Keyword(s): Muscle Regeneration, Multiphoton Absorption, Myofibers, Extracellular Matrix, Polyethylene Glycol-Fibrinogen, Hydrogel Matrix, C2C12, Cell Culture.

Related Ontology Subjects/Areas/Topics: Biomaterials ; Biomedical Engineering ; Biomedical Instruments and Devices ; Nanotechnologies

Abstract: The membrane-substrate interactions have a topological valence and represent a level of information exchange between the cell and the extra-cellular matrix and/or between cells. The interactions can vary with boundary conditions and can be altered by varying the chemical and/or physical properties of the substrate. The alteration can presumably result in differentiation or specialization of the cells, but this fundamental aspect must still be fully understood. In such a frame, we investigated the levels of transcriptional coactivators YAP/TAZ throughout C2C12 differentiation on standard two-dimensional substrates and on polyethylene glycol-fibrinogen three-dimensional microenvironment. In detail, we observed that the use of a three-dimensional matrix permits an earlier differentiation in muscular cells when compared to standard bidimensional substrates. On such a basis, we want to investigate the modulation of a more regular threedimensional pattern on cells proliferation response and we propose a matrix, generable with multiphoton absorption, with regular aligned channels in order to overcome the current limitation in muscle regeneration techniques, so a possible tool to improve the myofibers formation and alignment. (More)

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Paper citation in several formats:
Errico, V.; Molinaro, R.; Gargioli, C.; Ferranti, F.; Dinescu, M.; Cannata, S.; Saggio, G.; Rufini, S. and Desideri, A. (2016). Cells Microenvironment Engineering - Multiphoton Absorption for Muscle Regeneration Optimization.In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016) ISBN 978-989-758-170-0, pages 241-246. DOI: 10.5220/0005790402410246

@conference{biodevices16,
author={V. Errico. and R. Molinaro. and C. Gargioli. and F. Ferranti. and M. Dinescu. and S. Cannata. and G. Saggio. and S. Rufini. and A. Desideri.},
title={Cells Microenvironment Engineering - Multiphoton Absorption for Muscle Regeneration Optimization},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016)},
year={2016},
pages={241-246},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005790402410246},
isbn={978-989-758-170-0},
}

TY - CONF

JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016)
TI - Cells Microenvironment Engineering - Multiphoton Absorption for Muscle Regeneration Optimization
SN - 978-989-758-170-0
AU - Errico, V.
AU - Molinaro, R.
AU - Gargioli, C.
AU - Ferranti, F.
AU - Dinescu, M.
AU - Cannata, S.
AU - Saggio, G.
AU - Rufini, S.
AU - Desideri, A.
PY - 2016
SP - 241
EP - 246
DO - 10.5220/0005790402410246

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