Authors:
Septriyanto Dirgantara
1
;
Rosye H. R. Tanjung
1
;
Rahmawati Nurlatifah
1
and
Edy Meiyanto
2
Affiliations:
1
Universitas Cenderawasih, Indonesia
;
2
Gadjah Mada University, Indonesia
Keyword(s):
Cytotoxic, BSLT, Medicinal Plants, Papua
Abstract:
Background: Some medicinal plants from Papua which have been used traditionally as anticancer agents for many ethnic in Papua Islands. But, scientific evidence for this study were still limited. Objective: The present study was conducted to test for in vitro Brine Shrimp Lethality Test (BSLT) of the seven selected medicinal plants from Papua, namely, Drymis piperita (local name : Kayu Akway), Myrmecodia beccarii (Sarang semut), Biophytum petersianum (Rumput kebar), Vernonia amygdalina (Daun Afrika),Villebrunea rubescens( Daun Jilat), Laportea aestuans (Daun Gatal) and Breynia cernua (Katuk hutan). Methods: Seven ethanolic extracts were evaluated for their cytotoxic activity against Artemia salina Leach with concentration extracts from 10;100; and 1000 μg/mL. Cytotoxicity was evaluated in terms of LC 50 value from the 24 hour counts using the probit analysis method. Results: Ethanolic extracts of Myrmecodia beccarii showed the highest cytotoxicity with LC 50 was 8.33 μg/mL against bri
ne shrimp, but all selected medicinal plants showed the active potential cytotoxic activity because the LC 50 value were <1000 μg/mL. Conclusion: From this research, M.beccarii indicated the possible potential use of medicinal plants from Papua as anticancer agents.
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