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Authors: Wenyue Zhang 1 ; Markus Gnerlich 1 ; Yaohua Sun 1 ; Gaoshan Jing 1 ; Jonathan J. Paly 2 ; Arkady Voloshin 3 and Svetlana Tatic-Lucic 4

Affiliations: 1 Sherman Fairchild Center, United States ; 2 Bioengineering Program, United States ; 3 Bioengineering Program; Lehigh University, United States ; 4 Sherman Fairchild Center; Bioengineering Program, United States

Keyword(s): Cell mechanics, mechanical modulus, MEMS, polymer, dielectrophoresis.

Related Ontology Subjects/Areas/Topics: Biomechanical Devices ; Biomedical Engineering ; Biomedical Instruments and Devices ; Hardware ; MEMS ; Sensor Networks

Abstract: The measurements of the mechanical modulus of biological cells are critical to studies of pathophysiology and the research for an effective treatment. This research has developed a rapid and cost effective technique in order to measure the Poisson’s ratio and mechanical modulus of a live biological cell by utilizing microelectromechanical system (MEMS) techniques in a biological application. The design, fabrication, and characterization of a polymer-based MEMS system that integrates a V-shaped electrothermal actuator array and a cell-positioning system in a single microelectronics chip are presented here. This BioMEMS device compressed a NIH3T3 fibroblasts cell and caused up to 25% mechanical strain.

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Paper citation in several formats:
Zhang, W.; Gnerlich, M.; Sun, Y.; Jing, G.; J. Paly, J.; Voloshin, A. and Tatic-Lucic, S. (2008). POLYMER MEMS SYSTEM FOR MEASURING THE MECHANICAL MODULUS OF A BIOLOGICAL CELL. In Proceedings of the First International Conference on Biomedical Electronics and Devices (BIOSTEC 2008) - Volume 2: BIODEVICES; ISBN 978-989-8111- 17-3; ISSN 2184-4305, SciTePress, pages 146-150. DOI: 10.5220/0001052201460150

@conference{biodevices08,
author={Wenyue Zhang. and Markus Gnerlich. and Yaohua Sun. and Gaoshan Jing. and Jonathan {J. Paly}. and Arkady Voloshin. and Svetlana Tatic{-}Lucic.},
title={POLYMER MEMS SYSTEM FOR MEASURING THE MECHANICAL MODULUS OF A BIOLOGICAL CELL},
booktitle={Proceedings of the First International Conference on Biomedical Electronics and Devices (BIOSTEC 2008) - Volume 2: BIODEVICES},
year={2008},
pages={146-150},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001052201460150},
isbn={978-989-8111- 17-3},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the First International Conference on Biomedical Electronics and Devices (BIOSTEC 2008) - Volume 2: BIODEVICES
TI - POLYMER MEMS SYSTEM FOR MEASURING THE MECHANICAL MODULUS OF A BIOLOGICAL CELL
SN - 978-989-8111- 17-3
IS - 2184-4305
AU - Zhang, W.
AU - Gnerlich, M.
AU - Sun, Y.
AU - Jing, G.
AU - J. Paly, J.
AU - Voloshin, A.
AU - Tatic-Lucic, S.
PY - 2008
SP - 146
EP - 150
DO - 10.5220/0001052201460150
PB - SciTePress

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