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Authors: Benjamin Miraglio ; Gilles Bernot ; Jean-Paul Comet and Christine Risso-de Faverney

Affiliation: Université Côte d'Azur, France

ISBN: 978-989-758-214-1

ISSN: 2184-4305

Keyword(s): Computational Toxicology, Discrete Dynamic Systems, Rule-Based Modelling, Temporal Logic.

Related Ontology Subjects/Areas/Topics: Bioinformatics ; Biomedical Engineering ; Computational Molecular Systems ; Systems Biology

Abstract: Emerging constraints have led the toxicology community to complete the classical paradigm of toxicology with the study of molecular events underlying the toxicity of a chemical substance. This evolution motivates the emergence of new modelling approaches for toxicology. In this article, we introduce a qualitative rulebased formalism dedicated to the domain of toxicology. This new formalism departs from other rule-based formalisms such as BioChAM because it directly encodes possible alterations of equilibrium, instead of making equilibriums emerge from the dynamics of the model. Using a simple example of the energy metabolism, we show that this formalism is able to describe both the normal evolution of a biological system and its possible toxic disruptions.

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Paper citation in several formats:
Miraglio, B.; Bernot, G.; Comet, J. and Risso-de Faverney, C. (2017). A Qualitative Framework Dedicated to Toxicology. In Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2017) ISBN 978-989-758-214-1 ISSN 2184-4305, pages 93-103. DOI: 10.5220/0006168200930103

@conference{bioinformatics17,
author={Benjamin Miraglio. and Gilles Bernot. and Jean{-}Paul Comet. and Christine {Risso{-}de Faverney}.},
title={A Qualitative Framework Dedicated to Toxicology},
booktitle={Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2017)},
year={2017},
pages={93-103},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006168200930103},
isbn={978-989-758-214-1},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2017)
TI - A Qualitative Framework Dedicated to Toxicology
SN - 978-989-758-214-1
IS - 2184-4305
AU - Miraglio, B.
AU - Bernot, G.
AU - Comet, J.
AU - Risso-de Faverney, C.
PY - 2017
SP - 93
EP - 103
DO - 10.5220/0006168200930103

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