Authors:
Kamila Mazur
1
;
Renata Kalicka
1
;
Andrzej F. Frydrychowski
2
and
Pawel J. Winklewski
2
Affiliations:
1
Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, Poland
;
2
Medical University of Gdansk, Poland
Keyword(s):
Subarachnoid Space Width, Pial Artery, Brain Haemodynamics, Apnea, NIR-T/BSS.
Abstract:
Experiments were performed in a group of 19 healthy, non-smoking volunteers. The experiment consisted of three apnoeas, sequentially: 30 s apnoea, 60 s apnoea and maximal, that could be done, apnoea. The breath-hold was separated for 5 minutes rest. The following parameters were measured and obtained for further analysis: blood parameters, artery diameter of the internal carotid artery, end-tidal CO2 in expired air, the cardiac (from 0.5 to 5.0 Hz) and slow (< 0.5 Hz) components of subarachnoid space width signal. As a result of the experiment, we observed two different reactions, using the same experimental procedure. It seemed to indicate two different operating modes and two separate models. As a consequence, there are two subsets of slow subarachnoid space width responses to breath-hold in humans. A positive subarachnoid space width changes (slow) component depends on changes in heart rate, pulsatility index and cerebral blood flow velocity. A negative subarachnoid space width ch
anges component is driven by heart rate changes and pulsatility index changes. The different heart-generated arterial pulsation response to experimental breath-hold provides new insights into our understanding of the complex mechanisms governing the adaptation to apnoea in humans. We propose a mathematical methodology that can be used in further clinical research.
(More)