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Authors: Antonio Apicella and Raffella Aversa

Affiliation: Second University of Naples, Italy

Keyword(s): Biomimetics, Biomechanics, Hybrid nanostructured biomaterials, Piezoelectric.

Abstract: The research develops and tests new hybrid biomimetic materials that work as mechanically stimulating “scaffolds” to promote early regeneration in implanted bone healing phases. A biomometic nanostructured osteoconductive material coated apparatus is presented. Bioinspired approaches to materials and templated growth of hybrid networks using self-assembled hybrid organic-inorganic interfaces is finalized to extend the use of hybrids in the medical field. Combined in vivo, in vitro and computer-aided simulations have been carried out. Such multidisciplinary approach allowed us to explore many novel ideas in modelling, design and fabrication of new nanostructured biomaterials and scaffolds with enhanced functionality and improved interaction with OB cells. In vivo tests of Titanium screw implanted in rabbit tibiae have shown that mechanical stimulation was induced by the presence of bioactive hybrid perimplantar scaffold resulting in a differentiation and development of mesenchymal tis sues. In order to investigate the relationship between bone growth and applied mechanical loading (strain), a piezoelectically driven cantilever and a computer-controlled apparatus for "in vitro" tests has been developed and presented. (More)

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Paper citation in several formats:
Apicella, A. and Aversa, R. (2012). A BIOMIMETIC AND BIOMECHANICAL APPROACH FOR TISSUE ENGINEERING - Hybrid Nanomaterials and a Piezoelectric Tunable Bending Apparatus for Mechanically Stimulated Osteoblast Cells Growth. In Proceedings of the International Conference on Biomedical Electronics and Devices (BIOSTEC 2012) - BIODEVICES; ISBN 978-989-8425-91-1; ISSN 2184-4305, SciTePress, pages 280-285. DOI: 10.5220/0003887902800285

@conference{biodevices12,
author={Antonio Apicella. and Raffella Aversa.},
title={A BIOMIMETIC AND BIOMECHANICAL APPROACH FOR TISSUE ENGINEERING - Hybrid Nanomaterials and a Piezoelectric Tunable Bending Apparatus for Mechanically Stimulated Osteoblast Cells Growth},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices (BIOSTEC 2012) - BIODEVICES},
year={2012},
pages={280-285},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003887902800285},
isbn={978-989-8425-91-1},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the International Conference on Biomedical Electronics and Devices (BIOSTEC 2012) - BIODEVICES
TI - A BIOMIMETIC AND BIOMECHANICAL APPROACH FOR TISSUE ENGINEERING - Hybrid Nanomaterials and a Piezoelectric Tunable Bending Apparatus for Mechanically Stimulated Osteoblast Cells Growth
SN - 978-989-8425-91-1
IS - 2184-4305
AU - Apicella, A.
AU - Aversa, R.
PY - 2012
SP - 280
EP - 285
DO - 10.5220/0003887902800285
PB - SciTePress

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