Silica Coated Plasmonic Nanobone-based Tags for Safe Bioimaging

Aleksei Smirnov, Vasilisa Svinko, Aleksei Strelnikov, Alisa Shevchuk, Anna Volkova, Elena Solovyeva

2022

Abstract

Fluorescence tomography is a hopeful medical imaging technique. However, this method has restrictions consisting in absorbance and scattering of optical signal by tissue. The present research is devoted to overcome these challenges utilising plasmonic nanoparticles. A new type of gold nanoparticles was synthesized, having a bone-like shape which provides the maximum of unimodal absorption band just in the middle of the biological tissues transparency range (600-800 nm). The nanobones were further modified with cyanine 5.5 and 7 fluorophores by electrostatic immobilization and coated by silica shell via two different techniques to instill biocompatibility. Resulting nanoparticles were characterised by dynamic light scattering, transmission electron microscopy, fluorescent and Raman spectroscopy. It is shown that a thickness of silica shell may be tuned precisely and that the nanoparticles may also be coated directly using mercaptopropyltrimethxysilane. The registered surface-enhanced Raman scattering and fluorescent signals depend on a position of cyanine dye in nanoparticle shell. Intensive fluorescent signal from the nanoparticles covered with silicon dioxide using mercaptopropyltrimethxysilane proved an incorporation of cyanines into shell during its growth.

Paper Citation

in Harvard Style

Smirnov A., Svinko V., Strelnikov A., Shevchuk A., Volkova A. and Solovyeva E. (2022). Silica Coated Plasmonic Nanobone-based Tags for Safe Bioimaging. In Proceedings of the 10th International Conference on Photonics, Optics and Laser Technology - Volume 1: PHOTOPTICS, ISBN 978-989-758-554-8, pages 179-186. DOI: 10.5220/0010997700003121

in Bibtex Style

@conference{photoptics22,
author={Aleksei Smirnov and Vasilisa Svinko and Aleksei Strelnikov and Alisa Shevchuk and Anna Volkova and Elena Solovyeva},
title={Silica Coated Plasmonic Nanobone-based Tags for Safe Bioimaging},
booktitle={Proceedings of the 10th International Conference on Photonics, Optics and Laser Technology - Volume 1: PHOTOPTICS,},
year={2022},
pages={179-186},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010997700003121},
isbn={978-989-758-554-8},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 10th International Conference on Photonics, Optics and Laser Technology - Volume 1: PHOTOPTICS,
TI - Silica Coated Plasmonic Nanobone-based Tags for Safe Bioimaging
SN - 978-989-758-554-8
AU - Smirnov A.
AU - Svinko V.
AU - Strelnikov A.
AU - Shevchuk A.
AU - Volkova A.
AU - Solovyeva E.
PY - 2022
SP - 179
EP - 186
DO - 10.5220/0010997700003121