A Hybrid Approach using Progressive and Genetic Algorithms for Improvements in Multiple Sequence Alignments

Geraldo Zafalon, Geraldo Zafalon, Vitoria Gomes, Anderson Amorim, Anderson Amorim, Carlos Valêncio

Abstract

The multiple sequence alignment is one of the main tasks in bioinformatics. It is used in different important biological analysis, such as function and structure prediction of unknown proteins. There are several approaches to perform multiple sequence alignment and the use of heuristics and meta-heuristics stands out because of the search ability of these methods, which generally leads to good results in a reasonable amount of time. The progressive alignment and genetic algorithm are among the most used heuristics and meta-heuristics to perform multiple sequence alignment. However, both methods have disadvantages, such as error propagation in the case of progressive alignment and local optima results in the case of genetics algorithm. Thus, this work proposes a new hybrid refinement phase using a progressive approach to locally realign the multiple sequence alignment produced by genetic algorithm based tools. Our results show that our method is able to improve the quality of the alignments of all families from BAliBase. Considering Q and TC quality measures from BaliBase, we have obtained the improvements of 55% for Q and 167% for TC. Then, with these results we can provide more biologically significant results.

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Paper Citation


in Harvard Style

Zafalon G., Gomes V., Amorim A. and Valêncio C. (2021). A Hybrid Approach using Progressive and Genetic Algorithms for Improvements in Multiple Sequence Alignments. In Proceedings of the 23rd International Conference on Enterprise Information Systems - Volume 2: ICEIS, ISBN 978-989-758-509-8, pages 384-391. DOI: 10.5220/0010495303840391


in Bibtex Style

@conference{iceis21,
author={Geraldo Zafalon and Vitoria Gomes and Anderson Amorim and Carlos Valêncio},
title={A Hybrid Approach using Progressive and Genetic Algorithms for Improvements in Multiple Sequence Alignments},
booktitle={Proceedings of the 23rd International Conference on Enterprise Information Systems - Volume 2: ICEIS,},
year={2021},
pages={384-391},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010495303840391},
isbn={978-989-758-509-8},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 23rd International Conference on Enterprise Information Systems - Volume 2: ICEIS,
TI - A Hybrid Approach using Progressive and Genetic Algorithms for Improvements in Multiple Sequence Alignments
SN - 978-989-758-509-8
AU - Zafalon G.
AU - Gomes V.
AU - Amorim A.
AU - Valêncio C.
PY - 2021
SP - 384
EP - 391
DO - 10.5220/0010495303840391