Front-end Design Optimization for Ionoacoustic 200 MeV Protons Beam Monitoring with Sub-millimeter Precision for Hadron Therapy Applications

Elia Vallicelli, Elia Vallicelli, Mattia Cosmi, Andrea Baschirotto, Andrea Baschirotto, Marcello De Matteis, Marcello De Matteis

Abstract

This paper presents the design of a multichannel acoustic detector optimized for sensing proton induced thermo-acoustic signals (ionoacoustic signals) in clinical scenarios experiments. Ionoacoustics is a promising technique for real-time monitoring of proton beams with interesting possible applications in oncological hadron therapy. However, clinical scenarios are characterized by very low signal amplitudes (few tens millipascals). State-of-the-art experiments use general purpose acoustic sensors and heavily rely on averaging (up to thousands beam shots) to detect a clear signal, at the cost of a significant extra-dose above clinical limits. To overcome this limit, this paper presents the design of a dedicated acoustic sensor that exploits spatial correlation (multichannel sensor) to increase the SNR with no extra-dose and localize the maximum energy deposition of a 200 MeV proton beam in clinical scenarios (35 mGy/shot dose, 25 mPa signal amplitude). The results are validated by a complete cross-domain simulation of the physical (proton beam), acoustic (wave propagation) and electrical (sensor and electronics frequency response and noise) environments. The presented detector achieves a clear 20.5 dB single-shot SNR (35 mGy total dose) and can localize the maximum energy deposition with 0.5 mm precision (<1% w.r.t. the particle range) with ~1/100 dose reduction compared to state-of-the-art.

Download


Paper Citation


in Harvard Style

Vallicelli E., Cosmi M., Baschirotto A. and De Matteis M. (2021). Front-end Design Optimization for Ionoacoustic 200 MeV Protons Beam Monitoring with Sub-millimeter Precision for Hadron Therapy Applications.In Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, ISBN 978-989-758-490-9, pages 77-87. DOI: 10.5220/0010346600770087


in Bibtex Style

@conference{biodevices21,
author={Elia Vallicelli and Mattia Cosmi and Andrea Baschirotto and Marcello De Matteis},
title={Front-end Design Optimization for Ionoacoustic 200 MeV Protons Beam Monitoring with Sub-millimeter Precision for Hadron Therapy Applications},
booktitle={Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES,},
year={2021},
pages={77-87},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010346600770087},
isbn={978-989-758-490-9},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES,
TI - Front-end Design Optimization for Ionoacoustic 200 MeV Protons Beam Monitoring with Sub-millimeter Precision for Hadron Therapy Applications
SN - 978-989-758-490-9
AU - Vallicelli E.
AU - Cosmi M.
AU - Baschirotto A.
AU - De Matteis M.
PY - 2021
SP - 77
EP - 87
DO - 10.5220/0010346600770087