Assessing Preferred Proximity Between Different Types of Embryonic Stem Cells

Minhong Wang, Athanasios Tsanas, Guillaume Blin, Dave Robertson

Abstract

Embryonic stem cells (ESCs) studies play an important role for understanding the molecular events that underlie cell lineage commitment and serve as models for the development of disease. However, the interactions between neighboring embryonic stem cells are not fully understood. Assessing proximity between different types of embryonic stem cells might provide more information about distinct behaviors of embryonic stem cells. In this study, we processed 186 cell colonies on disc constrained microdomains and 152 cell colonies on ellipse. We grouped cell colonies based on different observed patterns and grouped cells by their locations. By applying two measurements on embryonic stem cell colonies, minimum spanning tree and average distance to the five closest objects, we investigated the difference of proximity between different types of embryonic stem cells, the difference between grouped cell colonies and the difference between grouped cells. We found one type of ESC has a smaller average path based on minimum spanning tree and higher proximity than the other type. We report consistent results for different types of embryonic stem cells: these findings may be useful to set benchmarks for empirical models which replicate ESC behaviors.

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Paper Citation


in Harvard Style

Wang M., Tsanas A., Blin G. and Robertson D. (2020). Assessing Preferred Proximity Between Different Types of Embryonic Stem Cells.In Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 4: SERPICO, ISBN 978-989-758-398-8, pages 377-381. DOI: 10.5220/0009368903770381


in Bibtex Style

@conference{serpico20,
author={Minhong Wang and Athanasios Tsanas and Guillaume Blin and Dave Robertson},
title={Assessing Preferred Proximity Between Different Types of Embryonic Stem Cells},
booktitle={Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 4: SERPICO,},
year={2020},
pages={377-381},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009368903770381},
isbn={978-989-758-398-8},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 4: SERPICO,
TI - Assessing Preferred Proximity Between Different Types of Embryonic Stem Cells
SN - 978-989-758-398-8
AU - Wang M.
AU - Tsanas A.
AU - Blin G.
AU - Robertson D.
PY - 2020
SP - 377
EP - 381
DO - 10.5220/0009368903770381