Theoretical Study of the Fidelity of Transcription

Yao-Gen Shu, Ming Li, Zhong-Can Ou-Yang

Abstract

This year we celebrate the 50th anniversary of the discovery of the three eukaryotic RNA polymerases. Ever since this seminal event was uncovered by Robert Roeder in 1969(Roeder and Rutter, 1969), researchers have investigated the intricate mechanisms of gene transcription with great dedication. However, there is not breakthrough in study of the fidelity of transcription still. Here, we propose a simplest model with first-order neighbor effects, a first-passage approach, to theoretically investigate the gene transcription fidelity.

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Paper Citation


in Harvard Style

Shu Y., Li M. and Ou-Yang Z. (2020). Theoretical Study of the Fidelity of Transcription.In Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, ISBN 978-989-758-398-8, pages 239-241. DOI: 10.5220/0009181002390241


in Bibtex Style

@conference{bioinformatics20,
author={Yao-Gen Shu and Ming Li and Zhong-Can Ou-Yang},
title={Theoretical Study of the Fidelity of Transcription},
booktitle={Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS,},
year={2020},
pages={239-241},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009181002390241},
isbn={978-989-758-398-8},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS,
TI - Theoretical Study of the Fidelity of Transcription
SN - 978-989-758-398-8
AU - Shu Y.
AU - Li M.
AU - Ou-Yang Z.
PY - 2020
SP - 239
EP - 241
DO - 10.5220/0009181002390241