Blue Light and Melanopsin Contribution to the Pupil Constriction in the Blind-spot, Parafovea and Periphery

Tim Schilling, Mojtaba Soltanlou, Yeshwanth Seshadri, Hans-Christoph Nuerk, Hamed Bahmani

Abstract

Retinal photoreceptors modulate the pupil diameter to regulate retinal illumination. At early stage the pupil-response is formed by intrinsically-photosensitive-Retinal-Ganglion-Cells (ipRGCs) expressing melanopsin, activated by blue light. ipRGCs’ axons pass through the optic nerve head, corresponding to the blind-spot. No photoreceptors except melanopsin appear to exist in the blind-spot. Contributions of melanopsin to pupil constriction in absence of classical photoreceptors in the blind-spot is not fully understood. We investigated how blue light in the blind-spot changes melanopsin-pupil-response compared to parafovea and periphery. The Post-Illumination-Pupil-Response (PIPR) amplitude reflecting melanopsin was analyzed for standardized time windows (1s<1.7s, 1s>1.8s and 2–6s) and expressed as pupillary-change. Bayesian analysis showed a BF>3 that PIPR>1.8s for blind-spot and periphery is not different. At times 2s–6s, a t-test comparison in the blind-spot condition showed a significantly larger PIPR to blue compared to red light, confirming a melanopsin-pupil-response in the blind-spot. Taken together, equivalent stimulation in the blind-spot and periphery revealed comparable PIPR, although there are no rods and cones in the blind-spot. In absence of classical photoreceptors in the blind-spot, melanopsin seems to be responsible for pupil constriction in similar manner as in the periphery, which supports the presence of melanopsin on the axons of ipRGCs.

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Paper Citation


in Harvard Style

Schilling T., Soltanlou M., Seshadri Y., Nuerk H. and Bahmani H. (2020). Blue Light and Melanopsin Contribution to the Pupil Constriction in the Blind-spot, Parafovea and Periphery.In Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 5: HEALTHINF, ISBN 978-989-758-398-8, pages 482-489. DOI: 10.5220/0008972404820489


in Bibtex Style

@conference{healthinf20,
author={Tim Schilling and Mojtaba Soltanlou and Yeshwanth Seshadri and Hans-Christoph Nuerk and Hamed Bahmani},
title={Blue Light and Melanopsin Contribution to the Pupil Constriction in the Blind-spot, Parafovea and Periphery},
booktitle={Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 5: HEALTHINF,},
year={2020},
pages={482-489},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008972404820489},
isbn={978-989-758-398-8},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 5: HEALTHINF,
TI - Blue Light and Melanopsin Contribution to the Pupil Constriction in the Blind-spot, Parafovea and Periphery
SN - 978-989-758-398-8
AU - Schilling T.
AU - Soltanlou M.
AU - Seshadri Y.
AU - Nuerk H.
AU - Bahmani H.
PY - 2020
SP - 482
EP - 489
DO - 10.5220/0008972404820489