Oral Delivery of ACE2 Bioencapsulated in Plant Cells as Potential Adjuvant Therapy to Reduce the COVID-19 Disease Severity

Eka B. Layadi, Robert Sinto, Friska W. Wijaya, Oemar Ichsan

Abstract

COVID-19 has become a widespread pandemic and a devastating public health emergency. Numerous trials have been conducted to search beneficial therapeutical interventions. ACE2 plays an essential role in the pathogenesis of SARS-CoV-2 infection as this receptor become the entry point of virus to the cell. The blockage of the ACE2 receptor and the delivery of ACE2 in the soluble form are some mechanisms that have been proposed for potential therapy of COVID-19. Parenteral administration of ACE2 in soluble form has been conducted in trials using the hrACE2 (human recombinant ACE2) and showed a favorable result. However, the possibility of administering ACE2 through an oral route has not been extensively explored. Bioencapsulated plant cell technique has shown resistant to digestive enzymes and gastric acid and able to carry ACE2 to be absorbed safely into the circulation. Previous study showed promising utilization of ACE2/Ang1-7 Bioencapsulated in Plant Cells to treat ocular inflammatory disorders in mice. Although no clinical studies have been done yet, similar concept can be theoretically applied to hinder the development of SARS-CoV-2 severe manifestation. The increasing soluble ACE2 may reduce the circulatory levels of detrimental Angiotensin II effects as well as acting as a decoy to bind free virions from attaching to the target cells.

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Paper Citation


in Harvard Style

Layadi E., Sinto R., Wijaya F. and Ichsan O. (2020). Oral Delivery of ACE2 Bioencapsulated in Plant Cells as Potential Adjuvant Therapy to Reduce the COVID-19 Disease Severity.In Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC, ISBN 978-989-758-499-2, pages 330-334. DOI: 10.5220/0010492103300334


in Bibtex Style

@conference{jimc20,
author={Eka B. Layadi and Robert Sinto and Friska W. Wijaya and Oemar Ichsan},
title={Oral Delivery of ACE2 Bioencapsulated in Plant Cells as Potential Adjuvant Therapy to Reduce the COVID-19 Disease Severity},
booktitle={Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,},
year={2020},
pages={330-334},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010492103300334},
isbn={978-989-758-499-2},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,
TI - Oral Delivery of ACE2 Bioencapsulated in Plant Cells as Potential Adjuvant Therapy to Reduce the COVID-19 Disease Severity
SN - 978-989-758-499-2
AU - Layadi E.
AU - Sinto R.
AU - Wijaya F.
AU - Ichsan O.
PY - 2020
SP - 330
EP - 334
DO - 10.5220/0010492103300334