The Effect of Jackfruit (Artocarpus heterophyllus) Leaf Ethanolic Extract Gel on Superoxide Dismutase and Interleukin-1β Levels in Wound Healing after Tooth Extraction in Diabetic Rats

Almasyifa Herlingga Rahmasari Amin, Yusuf Asto Pamasja, Christiana Cahyani Prihastuti, Haris Budi Widodo, Hernayanti

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia, which can cause complications, such as impaired wound healing after tooth extraction. The high level of blood glucose will increase ROS, leading to the degradation of SOD and elevation of IL-1β. Jackfruit leaf contains flavonoids with antioxidant and anti-inflammatory activities. This research aimed to study the effect of topical administration of jackfruit leaf ethanolic extract gel (JLEEG) after tooth extraction on SOD and IL-1β in gingiva tissue near tooth socket in diabetic rat models. The study was experimental laboratory research with a randomized posttest-only control group design. Thirty-five male Wistar rats were used as the sample and divided into 5 groups: T1, T2, T3 (diabetic rat groups treated with JLEEG concentrations of 5%, 10%, and 15% respectively), C1 (healthy control group), and C2 (negative control group). The treated groups showed higher SOD levels and lowered IL-1β levels in comparison to the negative control group. Statistical analysis using One-Way ANOVA indicated significant differences (p<0.01) between the treated groups and the negative control group. 15% was considered the most effective concentration to reduce the inflammation phase and accelerate the healing process of tooth extraction wounds in diabetic conditions.

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in Harvard Style

Rahmasari Amin A., Pamasja Y., Prihastuti C., Widodo H. and Hernayanti. (2020). The Effect of Jackfruit (Artocarpus heterophyllus) Leaf Ethanolic Extract Gel on Superoxide Dismutase and Interleukin-1β Levels in Wound Healing after Tooth Extraction in Diabetic Rats.In Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC, ISBN 978-989-758-499-2, pages 164-169. DOI: 10.5220/0010489501640169


in Bibtex Style

@conference{jimc20,
author={Almasyifa Herlingga Rahmasari Amin and Yusuf Asto Pamasja and Christiana Cahyani Prihastuti and Haris Budi Widodo and Hernayanti},
title={The Effect of Jackfruit (Artocarpus heterophyllus) Leaf Ethanolic Extract Gel on Superoxide Dismutase and Interleukin-1β Levels in Wound Healing after Tooth Extraction in Diabetic Rats},
booktitle={Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,},
year={2020},
pages={164-169},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010489501640169},
isbn={978-989-758-499-2},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,
TI - The Effect of Jackfruit (Artocarpus heterophyllus) Leaf Ethanolic Extract Gel on Superoxide Dismutase and Interleukin-1β Levels in Wound Healing after Tooth Extraction in Diabetic Rats
SN - 978-989-758-499-2
AU - Rahmasari Amin A.
AU - Pamasja Y.
AU - Prihastuti C.
AU - Widodo H.
AU - Hernayanti.
PY - 2020
SP - 164
EP - 169
DO - 10.5220/0010489501640169