Comparison of Purple Passion Juice (Passiflora edulis var. edulis) and Simvastatin on Lipid-lowering Effect of Hyperlipidemic Rats Model

Alfi Muntafiah, Tisna Sendy Pratama, Anisa Rachmawati, Dewi Wahyu Wulandari, Qodri Santosa

Abstract

Hyperlipidemia is a lipoprotein metabolic disorder characterized by high cholesterol and triglycerides in blood circulation. Non-pharmacological management efforts by consuming healthy foods are often the first choice. In the previous research, we found the antihypercholesterolemia potential of purple passion juice 4.2 mL/200gBB/day in experimental animals. This study aims to compare purple passion juice's effectiveness to Simvastatin in improving the lipid profile of the hyperlipidemic rats model. This true experimental study used 32 male Wistar rats, divided into 4 groups: K1 (normal control), K2 (hyperlipidemia control), K3 (purple passion juice 4.2 mL/200gBB/day), K4 (simvastatin 0.18 mg/200gBB/day). We used pork oil six mL/200gBB/day and Propylthiouracil (PTU) 12.5 mg/day, divided into two doses, for 14 days, by gavage, to induced hyperlipidemia. Blood sampling through retro-orbital veins was carried out at the end of induction (pre-test) and the end of the study (post-test) to measure the lipid profile. T-paired test on total cholesterol and triglyceride levels of the pre-post test showed a significant decrease in total cholesterol levels in K4 (p=0.00) and a significant decrease in triglyceride levels K3 (p=0.03), while in K1, there was a significant increase in both parameters. HDL levels decreased significantly in all groups. There was a significant difference in the one-way ANOVA test for both total cholesterol and triglyceride levels (p <0.05). Post Hoc test on post-test total cholesterol levels showed a significant difference in K2 v.s K4 (0.00), but there was no difference between K3 v.s K4 (p=0,54). The study concludes that Simvastatin was more effective in reducing total cholesterol levels; however, purple passion juice is more effective in lowering triglyceride levels.

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Paper Citation


in Harvard Style

Muntafiah A., Pratama T., Rachmawati A., Wulandari D. and Santosa Q. (2020). Comparison of Purple Passion Juice (Passiflora edulis var. edulis) and Simvastatin on Lipid-lowering Effect of Hyperlipidemic Rats Model.In Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC, ISBN 978-989-758-499-2, pages 148-154. DOI: 10.5220/0010489301480154


in Bibtex Style

@conference{jimc20,
author={Alfi Muntafiah and Tisna Sendy Pratama and Anisa Rachmawati and Dewi Wahyu Wulandari and Qodri Santosa},
title={Comparison of Purple Passion Juice (Passiflora edulis var. edulis) and Simvastatin on Lipid-lowering Effect of Hyperlipidemic Rats Model},
booktitle={Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,},
year={2020},
pages={148-154},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010489301480154},
isbn={978-989-758-499-2},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,
TI - Comparison of Purple Passion Juice (Passiflora edulis var. edulis) and Simvastatin on Lipid-lowering Effect of Hyperlipidemic Rats Model
SN - 978-989-758-499-2
AU - Muntafiah A.
AU - Pratama T.
AU - Rachmawati A.
AU - Wulandari D.
AU - Santosa Q.
PY - 2020
SP - 148
EP - 154
DO - 10.5220/0010489301480154