Correlation between Hepcidin and Ferritin with Insulin and Hba1C as Biochemical Markers of Pancreas Damage in β-Thalassemia Patients

Irbath Hamdani, Qodri Santosa, Joko Setyono, Hernayanti, Lantip Rujito

Abstract

Iron overload in β-thalassemia patients can damage various organs, including the pancreas. Impairment of the pancreas will be causing the failure and reduces insulin secretion, contributing to impaired glucose metabolism to diabetes mellitus in patients with β-thalassemia. This study analysed the correlation between hepcidin and ferritin levels as markers of iron overload with insulin levels and HbA1c as markers of pancreatic damage in patients with β thalassemia. Subjects of 35 thalassemia β patients were included in a cross-sectional study. Hepcidin, insulin, and HbA1c data were measured using the ELISA method. Ferritin data obtained through patient medical records. Bivariate analysis is using the Pearson test.: There were 97.1% of subjects with low hepcidin levels, whereas the ferritin data were in the high category. The data showed that 88.6% of subjects had low insulin levels. Most of the subjects (85.7%) were in the low category of HbA1c levels. Pearson test had a p-value = 0.001 which it indicates a significant relationship between hepcidin and insulin (r=0.771) and HbA1c (r=0.849). However, the ferritin levels showed no significant relationship with insulin (p=0.785 ; r=0.057) and HbA1c (p=0.420 ; r=0.169). In conclusion, the study found the lower the hepcidin level, the lower the insulin and HbA1c levels. Ferritin levels do not have a significant relationship with insulin and HbA1c levels.

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in Harvard Style

Hamdani I., Santosa Q., Setyono J., Hernayanti. and Rujito L. (2020). Correlation between Hepcidin and Ferritin with Insulin and Hba1C as Biochemical Markers of Pancreas Damage in β-Thalassemia Patients.In Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC, ISBN 978-989-758-499-2, pages 126-130. DOI: 10.5220/0010488901260130


in Bibtex Style

@conference{jimc20,
author={Irbath Hamdani and Qodri Santosa and Joko Setyono and Hernayanti and Lantip Rujito},
title={Correlation between Hepcidin and Ferritin with Insulin and Hba1C as Biochemical Markers of Pancreas Damage in β-Thalassemia Patients},
booktitle={Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,},
year={2020},
pages={126-130},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010488901260130},
isbn={978-989-758-499-2},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,
TI - Correlation between Hepcidin and Ferritin with Insulin and Hba1C as Biochemical Markers of Pancreas Damage in β-Thalassemia Patients
SN - 978-989-758-499-2
AU - Hamdani I.
AU - Santosa Q.
AU - Setyono J.
AU - Hernayanti.
AU - Rujito L.
PY - 2020
SP - 126
EP - 130
DO - 10.5220/0010488901260130