Effects of 8-Week Vitamin E (α Tocopherol) Supplementation on Reduced Insulin Resistance in Non-diabetic Obese Subjects

Erlina Marfianti, Isnatin Miladiyah

Abstract

Obesity is a risk factor for diabetes mellitus (DM) and coronary heart disease. In obesity, oxidative stress and adipokine hormone increase, leading to insulin resistance (IR) which can develop into DM. Vitamin E is an antioxidant that is expected to lower IR. This study aims to determine the effects of 8-week supplementation of vitamin E on reducing IR in non-diabetic obese subjects. The design was PROBE (Prospective Randomized Open Blinded End-point). The subjects were ≥18 years old with ≥25 kg/m2 body mass index and HOMA-IR value >2.7 The exclusion criteria were DM patients and those taking metformin or antioxidants. Twenty subjects in group A received 800 IU Vitamin E supplementation while 20 subjects in group B received placebo, both for 8 weeks. Reduced IR was measured from the decreasing HOMA-IR value after 8 weeks. The difference in decreasing HOMA-IR value between both groups was analyzed using independent t-test. The mean in group A was 0.199 ± 0.336, while group B had - 0.078 ± 0.271. The between both groups was statistically significant, with p = 0.004, 95% CI (0.096-0.457. Supplementation of 800 UI Vitamin E for 8 weeks could decrease IR in obese non-diabetic subjects.

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Paper Citation


in Harvard Style

Marfianti E. and Miladiyah I. (2020). Effects of 8-Week Vitamin E (α Tocopherol) Supplementation on Reduced Insulin Resistance in Non-diabetic Obese Subjects.In Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC, ISBN 978-989-758-499-2, pages 104-108. DOI: 10.5220/0010488501040108


in Bibtex Style

@conference{jimc20,
author={Erlina Marfianti and Isnatin Miladiyah},
title={Effects of 8-Week Vitamin E (α Tocopherol) Supplementation on Reduced Insulin Resistance in Non-diabetic Obese Subjects},
booktitle={Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,},
year={2020},
pages={104-108},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010488501040108},
isbn={978-989-758-499-2},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,
TI - Effects of 8-Week Vitamin E (α Tocopherol) Supplementation on Reduced Insulin Resistance in Non-diabetic Obese Subjects
SN - 978-989-758-499-2
AU - Marfianti E.
AU - Miladiyah I.
PY - 2020
SP - 104
EP - 108
DO - 10.5220/0010488501040108