Relaxation Effect of Ethanol Extract Black (EEB) on Plain Muscle Contraction from Insulated Guinea Pig’s Trakea by Acethyloline

Ramanathan, Ermi Girsang, Ali Napiah Nasution, I. Nyoman Ehrich Lister

Abstract

Indonesia, asthma is a chronic disease that occurs in respiratory tract that make difficulties breathing. This is reflected in the Household Health Survey Study data (SKRT) in various provinces in Indonesia. This study aims to determination of mechanism of relaxation on contraction smooth muscle of guinea pig’s trachea.. This research use in vitro model and use organ bath. The parameter measured in this research was contraction and relaxtion of isolated animal trachea. From this reaserch informed that EEBC (0.5-4 mg/ml) concentration effected the trachea smooth mucle and make it contract that induced by acetylcholine 1.43 x 10-4 M (r=0.982; p<0.05). The concentration of 4mg/ml EEBC, statistically there is no different with atropine sulfate 1 x 10-6 M in decrease the contraction of guinea pig’s trachea smooth muscle induced by acetylcholine 1.43 x 10-4 M (p>0.05). EEBC has been known have relaxing effect on smooth muscle especially trachea and has the potency to reduce the contraction of trachea contracted with acetylcholine. The action EEBC on isolated trachea was mediated by inhibition of the PDE enzyme.

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Paper Citation


in Harvard Style

Ramanathan., Girsang E., Nasution A. and Ehrich Lister I. (2020). Relaxation Effect of Ethanol Extract Black (EEB) on Plain Muscle Contraction from Insulated Guinea Pig’s Trakea by Acethyloline.In Proceedings of the International Conference on Health Informatics, Medical, Biological Engineering, and Pharmaceutical - Volume 1: HIMBEP, ISBN 978-989-758-500-5, pages 202-206. DOI: 10.5220/0010292902020206


in Bibtex Style

@conference{himbep20,
author={Ramanathan and Ermi Girsang and Ali Napiah Nasution and I. Nyoman Ehrich Lister},
title={Relaxation Effect of Ethanol Extract Black (EEB) on Plain Muscle Contraction from Insulated Guinea Pig’s Trakea by Acethyloline},
booktitle={Proceedings of the International Conference on Health Informatics, Medical, Biological Engineering, and Pharmaceutical - Volume 1: HIMBEP,},
year={2020},
pages={202-206},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010292902020206},
isbn={978-989-758-500-5},
}


in EndNote Style

TY - CONF

JO - Proceedings of the International Conference on Health Informatics, Medical, Biological Engineering, and Pharmaceutical - Volume 1: HIMBEP,
TI - Relaxation Effect of Ethanol Extract Black (EEB) on Plain Muscle Contraction from Insulated Guinea Pig’s Trakea by Acethyloline
SN - 978-989-758-500-5
AU - Ramanathan.
AU - Girsang E.
AU - Nasution A.
AU - Ehrich Lister I.
PY - 2020
SP - 202
EP - 206
DO - 10.5220/0010292902020206