Anti-Oxidative Potential of Acalypha indica L. Root Extract on Brain-Derived Neurotrophic Factor Levels in Old Sprague-Dawley Rats

Callen Zulkifli, Reganedgary Jonlean, Adisti Dwijayanti, Adisti Dwijayanti, Desak Gede Budi Krisnamurti, Desak Gede Budi Krisnamurti, Erni Hernawati Purwaningsih, Erni Hernawati Purwaningsih, Rani Wardani Hakim, Rani Wardani Hakim

2018

Abstract

Background: In 2020, life expectancy in Indonesia is estimated to be greater than 70 years. It implies an increasing number of elderly and becomes a major problem in the health sector. Aging is a process that involves oxidative stress; however, it can be anticipated by the presence of brain-derived neurotrophic factor (BDNF). Objective: The aim of this study is to investigate the effect of Acalypha indica L. (AI) as a notable medicinal plant to BDNF level changes as a marker of anti-aging. Methods: This experimental study was conducted in 28 days using male Sprague-Dawley rats. There were four groups identified: negative control, positive control (vitamin E 6 IU), treatment (AI 250 mg/kg BW), and young group (8-12 weeks of age rats). Data are collected from terminating all the rats and the brain tissues are further checked in the biochemistry laboratory. The test used for statistical analysis is one-way ANOVA. Results: Compared with the negative control group, levels of BDNF in brain tissues identified in the treatment group were increased, even though statistically insignificant (p-value = 0,6545). Nevertheless, the BDNF level in the negative control group is still higher than shown in the positive and young group. Conclusion: These results show that AI provides anti-oxidative properties; it also implies that AI can be used to impede the aging process. More studies are still needed to know the molecular mechanisms of action of AI that are particularly involved in increasing BDNF levels of brain tissues.

Paper Citation

in Harvard Style

Zulkifli C., Jonlean R., Dwijayanti A., Krisnamurti D., Purwaningsih E. and Hakim R. (2018). Anti-Oxidative Potential of Acalypha indica L. Root Extract on Brain-Derived Neurotrophic Factor Levels in Old Sprague-Dawley Rats. In Proceedings of BROMO Conference - Volume 1: BROMO, ISBN 978-989-758-347-6, pages 1-1. DOI: 10.5220/0009842000002406

in Bibtex Style

@conference{bromo18,
author={Callen Zulkifli and Reganedgary Jonlean and Adisti Dwijayanti and Desak Gede Budi Krisnamurti and Erni Hernawati Purwaningsih and Rani Wardani Hakim},
title={Anti-Oxidative Potential of Acalypha indica L. Root Extract on Brain-Derived Neurotrophic Factor Levels in Old Sprague-Dawley Rats},
booktitle={Proceedings of BROMO Conference - Volume 1: BROMO,},
year={2018},
pages={1-1},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009842000002406},
isbn={978-989-758-347-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of BROMO Conference - Volume 1: BROMO,
TI - Anti-Oxidative Potential of Acalypha indica L. Root Extract on Brain-Derived Neurotrophic Factor Levels in Old Sprague-Dawley Rats
SN - 978-989-758-347-6
AU - Zulkifli C.
AU - Jonlean R.
AU - Dwijayanti A.
AU - Krisnamurti D.
AU - Purwaningsih E.
AU - Hakim R.
PY - 2018
SP - 1
EP - 1
DO - 10.5220/0009842000002406