In Vitro Evaluation of Antacid and Anti-flatulent Activity in Ethanolic Extract Syrup of Clove Leaves (Eugenia Caryophyllata Thunberg)

Nurul Widi, Retno Widyowati, Herra Studiawan, Sukardiman

Abstract

Objective: Peptic ulcer has high prevalence in the world caused by high gastric acid. The sample of this study is ethanolic extract syrup of clove leaves (Eugenia Caryophyllata Thunberg) which has gastroprotective and antiulcer activities. Methods: The pH of ethanolic extract syrup of clove leaves (Eugenia Caryophyllata Thunberg) and their neutralizing effects on artificial gastric acids were determined and compared with negative and positive controls, aluminium hydroxide and magnesium hydroxide. A modified model of Vatier’s artificial stomach was used to determine the duration of consistent neutralization effect on artificial gastric acids. The neutralization capacity in vitro was determined with the titration method of Wu model. Rezak method was used to test the antiflatulent activity by creating foam from sodium lauryl sulfate. The syrup was subsequently added and the remaining height of foam formed was calculated. Results: The results showed that both ethanolic extract syrup of clove leaves (Eugenia Caryophyllata Thunberg) have antacid and antiflatulence effects in vitro. Compared with the water group, ethanolic extract syrup of clove leaves (Eugenia Caryophyllata Thunberg) were found to possess significant gastric acid neutralizing effects. The duration for consistent neutralization of Ethanolic extract syrup of clove leaves (Eugenia Caryophyllata Thunberg) was significantly longer than that of water. Also, there are have antiflatulence effects by decrease of foaming in vitro model. Conclusion : Ethanolic extract syrup of clove leaves (Eugenia Caryophyllata Thunberg) were consistently active in the artificial stomach model and are suggested to have antacid and antiflatulence effects similar to the active control drugs.

Paper Citation

in Harvard Style

Widi N., Widyowati R., Studiawan H. and Sukardiman. (2018). In Vitro Evaluation of Antacid and Anti-flatulent Activity in Ethanolic Extract Syrup of Clove Leaves (Eugenia Caryophyllata Thunberg).In Proceedings of BROMO Conference - Volume 1: BROMO, ISBN 978-989-758-347-6, pages 272-276. DOI: 10.5220/0008361102720276

in Bibtex Style

@conference{bromo18,
author={Nurul Widi and Retno Widyowati and Herra Studiawan and Sukardiman},
title={In Vitro Evaluation of Antacid and Anti-flatulent Activity in Ethanolic Extract Syrup of Clove Leaves (Eugenia Caryophyllata Thunberg)},
booktitle={Proceedings of BROMO Conference - Volume 1: BROMO,},
year={2018},
pages={272-276},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008361102720276},
isbn={978-989-758-347-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of BROMO Conference - Volume 1: BROMO,
TI - In Vitro Evaluation of Antacid and Anti-flatulent Activity in Ethanolic Extract Syrup of Clove Leaves (Eugenia Caryophyllata Thunberg)
SN - 978-989-758-347-6
AU - Widi N.
AU - Widyowati R.
AU - Studiawan H.
AU - Sukardiman.
PY - 2018
SP - 272
EP - 276
DO - 10.5220/0008361102720276