Effects of Gambir (Uncaria gambir Roxb) Catechins on Burn Wound Healing in Male Rats

Muhammad Yanis Musdja, Lina Elvita, Nursetyowati Rahayu

Abstract

Background: Indonesia is the largest Uncaria gambir, Roxb (gambir) producing country in the world, but its benefits as a medicinal plant has not been optimally developed. Traditionally, gambir plants have been widely used by a lot of people as burn wound healing. Objective: This study aims to determine the effect of gambir catechins crude for burn wound healing through histopathological observations on white rats male. Methods: Gambir Catechins crude was isolated by using partition method with ethyl acetate solvent. The rats were made to suffer burn wound based on Akhoondinasab methods et al. A total of 30 male white rats were divided into 5 groups and given daily test preparations. A total of 3 groups were given gambir catechins crude gel with variations of concentrations of 1%, 2% and 4%), for positive control group was used a commercial drug that contains 10% placenta extract and 0.5% Neomycin sulfate and one other group was used as a negative control. After administration of test preparation for 21 days, histopathology changes was observed in the burn wound that occurred. Results: Statistical analysis showed that gel gambir catechins crude with concentrations 2% had effect of decreasing the burn wound area and an increase in the percentage of healing of burn wound that did not differ significantly from positive controls (P <0.05). Histopathologic observations showed that catechins crude of gambir were able to reduce the number of inflammatory cells and increase neocapillary formation compared with the negative control group. Conclusion: Gambir catechins crude with concentration 2 % could help the healing process of second degree of burn wound on the inflammatory phase and proliferation.

Paper Citation

in Harvard Style

Musdja M., Elvita L. and Rahayu N. (2018). Effects of Gambir (Uncaria gambir Roxb) Catechins on Burn Wound Healing in Male Rats.In Proceedings of BROMO Conference - Volume 1: BROMO, ISBN 978-989-758-347-6, pages 261-271. DOI: 10.5220/0008361002610271

in Bibtex Style

@conference{bromo18,
author={Muhammad Yanis Musdja and Lina Elvita and Nursetyowati Rahayu},
title={Effects of Gambir (Uncaria gambir Roxb) Catechins on Burn Wound Healing in Male Rats},
booktitle={Proceedings of BROMO Conference - Volume 1: BROMO,},
year={2018},
pages={261-271},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008361002610271},
isbn={978-989-758-347-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of BROMO Conference - Volume 1: BROMO,
TI - Effects of Gambir (Uncaria gambir Roxb) Catechins on Burn Wound Healing in Male Rats
SN - 978-989-758-347-6
AU - Musdja M.
AU - Elvita L.
AU - Rahayu N.
PY - 2018
SP - 261
EP - 271
DO - 10.5220/0008361002610271