Analgesic Activity of Ethanol Extract of Rhaphidophora pinnata L.f Schott Leaves in Mice Induced by Acetic Acid

Sumaiyah, Masfria, Aminah Dalimunthe

Abstract

Rhaphidophora pinnata, Araceae Family, were suspected able to reduce pain. This study aimed to determine the effect of Rhaphidophora pinnata to reduce pain by acetic acid induced writhing response in mice. This effect was examined by the acetic acid induced writhing response in mice. The animals were divided into five groups (n=5) and received ethanol extract of Rhaphidophora pinnata leaves at doses of 50, 100 and 200 mg/kg BW, Sodium CMC 0.5% as negative control and acetosal 200 mg/kg BW as positive control. These preparations were given orally 30 minutes before the given acetic acid 3% (w/v) as the pain inductor. Analgesic activity was measured by counting the percentage of writhing movements. The study showed that all of dose ethanol extract of Rhapidophora pinnata gave significant pain reduction in mice induced by acetic acid (p<0.05) compared to control group. The effective dose was shown by ethanol extract of Rhaphidophora pinnata 50 mg/kg BW. Ethanol extract of Rhaphidophora pinnata leaves can reduce pain in mice induced by acetic acid.

Paper Citation

in Harvard Style

Sumaiyah., Masfria. and Dalimunthe A. (2018). Analgesic Activity of Ethanol Extract of Rhaphidophora pinnata L.f Schott Leaves in Mice Induced by Acetic Acid.In Proceedings of BROMO Conference - Volume 1: BROMO, ISBN 978-989-758-347-6, pages 224-226. DOI: 10.5220/0008360402240226

in Bibtex Style

@conference{bromo18,
author={Sumaiyah and Masfria and Aminah Dalimunthe},
title={Analgesic Activity of Ethanol Extract of Rhaphidophora pinnata L.f Schott Leaves in Mice Induced by Acetic Acid},
booktitle={Proceedings of BROMO Conference - Volume 1: BROMO,},
year={2018},
pages={224-226},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008360402240226},
isbn={978-989-758-347-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of BROMO Conference - Volume 1: BROMO,
TI - Analgesic Activity of Ethanol Extract of Rhaphidophora pinnata L.f Schott Leaves in Mice Induced by Acetic Acid
SN - 978-989-758-347-6
AU - Sumaiyah.
AU - Masfria.
AU - Dalimunthe A.
PY - 2018
SP - 224
EP - 226
DO - 10.5220/0008360402240226