Antiproliferative and Apoptotic Induction of n-Hexane Fraction of Picria fel-terrae lour. Herbs on T47D Cell Line

Denny Satria, Jansen Silalahi, Ginda Haro, Syafruddin Ilyas

Abstract

A recent research reported that breast cancer is leading to the estimated new cancer cases, and the second most incidence death cause of women affictioning from cancer. This research aim is to evaluate cytotoxic, antiproliferative and apoptotic induction activities of n-hexane fraction (nHF) of Picria fel-terrae Lour. herbs. Cytotoxic activity of nHF was determined with MTT method, cell cycle and apoptotic analysis were determined with flow cytometry method towards T47D cell line. Cytotoxic activity from nHF with MTT assay measured as IC 50 was 75.87 ± 0.75 µg/mL, nHF at 15 µg/mL caused accumulation in G 2 -M (37.47%) and S phase accumulation (19.41%) and increased early (24.25%) and late apoptosis (4.26%). The results reveal that nHF of Picria fel-terrae Lour. herbs have antiproliferative and apoptotic induction activities. Our further study is to isolation anticancer compounds from Picria fel-terrae Lour. herbs.

Paper Citation

in Harvard Style

Satria D., Silalahi J., Haro G. and Ilyas S. (2018). Antiproliferative and Apoptotic Induction of n-Hexane Fraction of Picria fel-terrae lour. Herbs on T47D Cell Line.In Proceedings of BROMO Conference - Volume 1: BROMO, ISBN 978-989-758-347-6, pages 190-193. DOI: 10.5220/0008359701900193

in Bibtex Style

@conference{bromo18,
author={Denny Satria and Jansen Silalahi and Ginda Haro and Syafruddin Ilyas},
title={Antiproliferative and Apoptotic Induction of n-Hexane Fraction of Picria fel-terrae lour. Herbs on T47D Cell Line},
booktitle={Proceedings of BROMO Conference - Volume 1: BROMO,},
year={2018},
pages={190-193},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008359701900193},
isbn={978-989-758-347-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of BROMO Conference - Volume 1: BROMO,
TI - Antiproliferative and Apoptotic Induction of n-Hexane Fraction of Picria fel-terrae lour. Herbs on T47D Cell Line
SN - 978-989-758-347-6
AU - Satria D.
AU - Silalahi J.
AU - Haro G.
AU - Ilyas S.
PY - 2018
SP - 190
EP - 193
DO - 10.5220/0008359701900193