Composition Ratio of Lactose and Corn Starch in Granule Capsule Formulation of 70% Ethanol Extract Justicia gendarussa Leaves as Male Contraceptive

Bambang Prajogo EW, Esti Hendradi, Pramudita Riwanti

Abstract

The objective of this study were to make a good physical properties of Justicia gendarussa granules with lactose and corn starch as filler. Optimizations were made into 3 formulas. The difference of each formula was in the ratio of corn starch and lactose. Formula 1 used ratio 3:7 for corn starch and lactose, Formula 2 used ratio 1:1 for lactose and corn starch, Formula 3 used ratio 7:3 for corn starch and lactose. Physical evaluation was held to evaluate and choose the best granule like flowability, fines content, angle of repose, moisture content, compressibility. The result for granules optimization, flowability formula 1 was 3,29 ± 1,08 g/s, formula 2 was 6,04 ± 1,80 g/s, formula 3 was 6,48 ± 1,32 g/s. Angle of repose for F1,2 and 3 were 30,54 ± 1,14 o , 29,98 ± 0,34 o and 26,98 ± 0,00 o . Compressibilty index were 12,00% , 10,00% and 11,99%. Moisture content 1,82%, 2,08% and 2,75%. Fines content were above 20%. From the evaluation, F2 was selected as the best formula.

Paper Citation

in Harvard Style

Prajogo EW B., Hendradi E. and Riwanti P. (2018). Composition Ratio of Lactose and Corn Starch in Granule Capsule Formulation of 70% Ethanol Extract Justicia gendarussa Leaves as Male Contraceptive.In Proceedings of BROMO Conference - Volume 1: BROMO, ISBN 978-989-758-347-6, pages 183-189. DOI: 10.5220/0008359601830189

in Bibtex Style

@conference{bromo18,
author={Bambang Prajogo EW and Esti Hendradi and Pramudita Riwanti},
title={Composition Ratio of Lactose and Corn Starch in Granule Capsule Formulation of 70% Ethanol Extract Justicia gendarussa Leaves as Male Contraceptive},
booktitle={Proceedings of BROMO Conference - Volume 1: BROMO,},
year={2018},
pages={183-189},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008359601830189},
isbn={978-989-758-347-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of BROMO Conference - Volume 1: BROMO,
TI - Composition Ratio of Lactose and Corn Starch in Granule Capsule Formulation of 70% Ethanol Extract Justicia gendarussa Leaves as Male Contraceptive
SN - 978-989-758-347-6
AU - Prajogo EW B.
AU - Hendradi E.
AU - Riwanti P.
PY - 2018
SP - 183
EP - 189
DO - 10.5220/0008359601830189