Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate

Lusi Putri Dwita, Vivi Anggia, Tri Dewi Prasetyatuti

Abstract

Background: The search for effective antidiabetic drugs remains to be a focus of research in the world. Artocarpus have been used as traditional medicine in South-East Asia. One of the species, Artocarpus altilis has been known in Indonesia as traditional treatment for diabetic. Objective: This research aimed to discover α-amylase inhibitor activity of Artocarpus altilis leaves. Methods: Leaves were extracted by maceration method, followed by phytochemical screening and quercetin identification using LC-MS method. Inhibition of α-amylase was measured using UV-Vis spectrophotometer at 524 nm wavelength, while antioxidant activity was determined using DPPH. Results: Artocarpus altilis leaves ethanol extract exhibited activity against α-amylase with 155.96 ppm IC50 (0.27 times relative potential compared to acarbose) and the extract showed antioxidant activity with the IC50 of 999.96 ppm. Conclusion: Artocarpus altilis showed activity as the α-amylase inhibitor.

Paper Citation

in Harvard Style

Dwita L., Anggia V. and Prasetyatuti T. (2018). Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate.In Proceedings of BROMO Conference - Volume 1: BROMO, ISBN 978-989-758-347-6, pages 168-173. DOI: 10.5220/0008359301680173

in Bibtex Style

@conference{bromo18,
author={Lusi Putri Dwita and Vivi Anggia and Tri Dewi Prasetyatuti},
title={Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate},
booktitle={Proceedings of BROMO Conference - Volume 1: BROMO,},
year={2018},
pages={168-173},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008359301680173},
isbn={978-989-758-347-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of BROMO Conference - Volume 1: BROMO,
TI - Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate
SN - 978-989-758-347-6
AU - Dwita L.
AU - Anggia V.
AU - Prasetyatuti T.
PY - 2018
SP - 168
EP - 173
DO - 10.5220/0008359301680173