Table 1. The result of serotyping study in 17 positive
dengue-infected samples from 2012 to 2014
4 CONCLUSIONS
This study has observed the first molecular data of
DENV in Bangkalan, Madura Island, Indonesia.
Serotype predominance is similar to that from
molecular surveillance study in Surabaya,
suggesting the endemic nature of the infecting virus
that caused a high prevalence of dengue in
Bangkalan. This study shows the importance of
continuous virus surveillance in dengue endemic
areas better understanding in the dynamic of dengue
infection disease in Indonesia.
ACKNOWLEDGEMENTS
This work was supported by the joined program of the
Japan Initiative for Global Research Network on
Infectious Disease (J-GRID); Syarifah Ambami Rato Ebu
General Hospital, Bangkalan, Madura Island, East Java
Province, Indonesia; and Institute of Tropical Disease
(ITD) the Center of Excellence (COE) program by the
Ministry of Research and Technology (RISTEK)
Indonesia.
REFERENCES
Department of Health East Java Province, 2013.
Profile of Health East Java Province in 2012.
Available:
<http://www.depkes.go.id/resources/download/pr
ofil/PROFIL_KES_PROVINSI_2012/15_Profil_
Kes.Prov.JawaTimur_2012.pdf>. (29.07.2015).
Fahri, S., Yohan, B., Trimarsanto, H., Sayono, S.,
Hadisaputro, S., Dharmana, E., Syafruddin, D.,
Sasmono, RT., 2013. Molecular Surveillance of
Dengue in Semarang, Indonesia Revealed the
Circulation of an Old Genotype of Dengue Virus
Serotype-1. Plos Neglected Tropical Disease, 7,
1-12
Green, S., Rothman, A., 2006. Immunothological
mechanisms in dengue and dengue fever.
Current Opinion in Infectious Diseases, 19, 429-
436
Gubler, DJ., 2002. Endemic dengue/dengue
hemorrhagic fever as apublic health, social and
economic problem in the 21
st
century. TRENDS
in Microbiology, 10, 100-103
Hotta, S., Aoki, H., Samoto, S., Yasui, T., Noerjasin,
B., 1970. Virologic-epidemiological studies on
Indonesia. 3. HI antibodies against selected
arboviruses (groups A and B) in human and
animal sera collected in Surabaja, East Java, in
1968. Kobe Journal of Medical Science, 16, 235-
250
Konishi, E., Tabuchi, Y., Yamanaka, A., 2010. A
simple assay system for infection-enhancing and
–neutralizing antibodies to dengue type 2 virus
using layers of semi-adherent K562 cells.
Journal of Virological Methods, 163, 360-367
Kotaki, T., Yamanaka, A., Mulyatno, KC.,
Churrotin, S., Labiqah, A., Sucipto, TH.,
Soegijanto, S., Kameoka, M., Konishi, E., 2014.
Continuous dengue type 1 virus genotype shifts
followed by co-circulation, clade shifts and
subsequent disapprearance in Surabaya,
Indonesia, 2008-2013. Infection, Genetics and
Evolution, 28, 48-54
Lanciotti, RS., Calisher, CH., Gubler, DJ., Chang,
G., Vorndam, AV., 1992. Rapid Detection and
Typing of Dengue Viruses from Clinica;
Samples by Using Reverse Transcriptase-
Polymerase Chain Reaction. Journal of Clinical
Microbiology, 30, 545-551
Martina, BEE., Koraka, P., Osterhaus, ADME,.
2009. Dengue Virus Pathogenesis: an Integrated
View. Clinical Microbiology Reviews, 22, 564-
581
Nusa, R., Prasetyowati, H., Meutiawati, F., Yohan,
B., Trimarsanto, H., Setianinsih, TY., Sasmono,
RT., 2014. Molecular surveillance of Dengue in
Sukabumi, West Java province, Indonesia. The
Journal of Infectious Developing Countries, 8,
733-741
BROMO 2018 - Bromo Conference, Symposium on Natural Products and Biodiversity
166