The Utilization of Graptophyllum pictum (L) Griff. Extract as the Endometrial and Myometrial Hyperplasia Inhibitor of Ovariectomized Mice

Listijani Suhargo, Dwi Winarni

Abstract

Endometrial and myometrial hyperplasia was caused as a side effect of estradiol hormone using for menopausal condition and it could change to be cancer. Graptophyllum pictum (L) Griff. (Daun wungu) ethanol extract with its flavonoid competes with estradiol to bind the estrogen reseptor and decreases the side effect of estradiol. The aim of this research was conducted to evaluate the utilization of daun wungu ethanol extracts as the endometrial and myometrial hyperplasia inhibitor of ovariectomy mice. This researches used 30 ovariectomized mice. The ovariectomized mice were grouped in 5 groups, one group control group with 3 µg/kg ethynil estradiol/EE), 4 groups for the treatment with 3 µg/kg EE with 25 mg/kg, 37,5 mg/kg, 50 mg/kg and 62,5 mg/kg daun wungu extracts in coconut oil. All treatments were done by oral for 30 days. At the end of the treatments, all mice was sacrificed and were made histology preparation of uterus. The result showed that daun wungu ethanol extracts could inhibit endometrium and myometrium hyperplasia that were showed in the thickness of those tissues of ovariectomized mice. And 37,5 mg/kg daun wungu extract was optimal dose for hyperplasia inhibitor of those tissues.

Paper Citation

in Harvard Style

Suhargo L. and Winarni D. (2018). The Utilization of Graptophyllum pictum (L) Griff. Extract as the Endometrial and Myometrial Hyperplasia Inhibitor of Ovariectomized Mice.In Proceedings of BROMO Conference - Volume 1: BROMO, ISBN 978-989-758-347-6, pages 102-105. DOI: 10.5220/0008358101020105

in Bibtex Style

@conference{bromo18,
author={Listijani Suhargo and Dwi Winarni},
title={The Utilization of Graptophyllum pictum (L) Griff. Extract as the Endometrial and Myometrial Hyperplasia Inhibitor of Ovariectomized Mice},
booktitle={Proceedings of BROMO Conference - Volume 1: BROMO,},
year={2018},
pages={102-105},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008358101020105},
isbn={978-989-758-347-6},
}

in EndNote Style

TY - CONF

JO - Proceedings of BROMO Conference - Volume 1: BROMO,
TI - The Utilization of Graptophyllum pictum (L) Griff. Extract as the Endometrial and Myometrial Hyperplasia Inhibitor of Ovariectomized Mice
SN - 978-989-758-347-6
AU - Suhargo L.
AU - Winarni D.
PY - 2018
SP - 102
EP - 105
DO - 10.5220/0008358101020105