Variability in The Response to Low Impact Aerobic Exercise in Women Abdominal Obese With the Polymorphism of Uncoupling Protein-1 Gene

D Mukhtar, Siagian M, N Ibrahim, Neng Tine, T Ahmad, M Suryaatmadja, SW Jusman, AS Sofro, M Abdullah, S Waspadji, S Sugondo

2017

Abstract

Abstract: Overweight and obesity were the accumulation of excessive fat that could harm health. Obesity was a risk for cardio-metabolic disorders. The polymorphism of UCP1 gene caused variations in response to regular exercise. This study aims to investigate the influence of low impact aerobics exercise (LIAE) in abdominal obese women who had the polymorphism of UCP1 gene on cardio-metabolic parameters, waist circumference (WC), levels of triglyceride (TG) and inflammatory markers Monocyte Chemo-attractant Protein-1 (MCP1). The study design was non-randomized controlled trial. A total of 55 women subjects moderately obese women were divided into two groups on the basis of location. Thirty-two subjects of LIAE group and 23 a non LIAE controled group. Outcome assessments for analyses were completed at baseline and 12 weeks for cardio-metabolic parameters WC, TG and MCP1. Examination of the polymorphism -3826 A> G UCP1 gene using PCR technique followed by RFLP technique. The frequencies of three genotypes of -3826 A> G polymorphism of UCP1 gene were AA, AG, and GG were of 21 (38.2%), 27(49.1%) and 7 (12.7%) respectively with the G allele frequency of 0.40%. Post study obtained the subjects with TG baseline ≥ 130 mg/dL 100% LIAE responders group, Control 55%, while TG <130 mg / dL group 22%. The GG genotypes subjects of UCP1 polymorphism gene with TG ≥ 130 mg/dL were high responders whereas the AA genotypes were low responders. The result was speculated to be due to number of steps per day subjects with TG ≥ 130 mg/dL and GG genotype group of LIAE was higher than non-responders group.

Paper Citation

in Harvard Style

Mukhtar D., M S., Ibrahim N., Tine N., Ahmad T., Suryaatmadja M., Jusman S., Sofro A., Abdullah M., Waspadji S. and Sugondo S. (2017). Variability in The Response to Low Impact Aerobic Exercise in Women Abdominal Obese With the Polymorphism of Uncoupling Protein-1 Gene.In Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS, ISBN 978-989-758-340-7, pages 62-66. DOI: 10.5220/0007332800620066

in Bibtex Style

@conference{sips17,
author={D Mukhtar and Siagian M and N Ibrahim and Neng Tine and T Ahmad and M Suryaatmadja and SW Jusman and AS Sofro and M Abdullah and S Waspadji and S Sugondo},
title={Variability in The Response to Low Impact Aerobic Exercise in Women Abdominal Obese With the Polymorphism of Uncoupling Protein-1 Gene},
booktitle={Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,},
year={2017},
pages={62-66},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007332800620066},
isbn={978-989-758-340-7},
}

in EndNote Style

TY - CONF

JO - Proceedings of Surabaya International Physiology Seminar - Volume 1: SIPS,
TI - Variability in The Response to Low Impact Aerobic Exercise in Women Abdominal Obese With the Polymorphism of Uncoupling Protein-1 Gene
SN - 978-989-758-340-7
AU - Mukhtar D.
AU - M S.
AU - Ibrahim N.
AU - Tine N.
AU - Ahmad T.
AU - Suryaatmadja M.
AU - Jusman S.
AU - Sofro A.
AU - Abdullah M.
AU - Waspadji S.
AU - Sugondo S.
PY - 2017
SP - 62
EP - 66
DO - 10.5220/0007332800620066