CHITOSAN FOR MEMS - Demonstration of Micromechanical and Optical Biosensors

Stephan T. Koev, Peter H. Dykstra, Reza Ghodssi, Gary W. Rubloff, William E. Bentley, Gregory F. Payne

2009

Abstract

This paper presents the biological functionalization of MEMS sensors by using the polysaccharide chitosan. Chitosan is a unique polymer due to its abundance of primary amine groups and its ability to be electrodeposited with spatial and temporal control. Biomolecules such as DNA and proteins can be attached to chitosan films by standard coupling chemistries. This biofunctionalization approach was demonstrated for two different MEMS devices: a microcantilever and an optical sensor. The devices were coated with chitosan and probe DNA and were used for detecting the hybridization with target DNA. Here, we describe the design, fabrication procedure, and testing results for both of these biosensors.

References

  1. Badilita, V., Shamim, I., Yi, H., Koev, S. T., Gerasopoulos, K. & Ghodssi, R. (2007) ChitosanMediated Biomems Platform For Optical Sensing. The 14th International Conference On Solid-State Sensors, Actuators, And Microsystems (Transducers 7807). Lyon, France.
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  3. Koev, S. T., Powers, M. A., Yi, H., Wu, L.-Q., Bentley, W. E., Rubloff, G. W., Payne, G. F. & Ghodssi, R. (2007) Mechano-Transduction Of Dna Hybridization And Dopamine Oxidation Through Electrodeposited Chitosan Network. Lab On A Chip, 7, 103-111.
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Paper Citation


in Harvard Style

Koev S., Dykstra P., Ghodssi R., Rubloff G., Bentley W. and Payne G. (2009). CHITOSAN FOR MEMS - Demonstration of Micromechanical and Optical Biosensors . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2009) ISBN 978-989-8111- 64-7, pages 109-112. DOI: 10.5220/0001552801090112


in Bibtex Style

@conference{biodevices09,
author={Stephan T. Koev and Peter H. Dykstra and Reza Ghodssi and Gary W. Rubloff and William E. Bentley and Gregory F. Payne},
title={CHITOSAN FOR MEMS - Demonstration of Micromechanical and Optical Biosensors},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2009)},
year={2009},
pages={109-112},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001552801090112},
isbn={978-989-8111- 64-7},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2009)
TI - CHITOSAN FOR MEMS - Demonstration of Micromechanical and Optical Biosensors
SN - 978-989-8111- 64-7
AU - Koev S.
AU - Dykstra P.
AU - Ghodssi R.
AU - Rubloff G.
AU - Bentley W.
AU - Payne G.
PY - 2009
SP - 109
EP - 112
DO - 10.5220/0001552801090112