Authors:
Abdul-Hakeem H. AlOmari
1
;
Andis Graudins
2
and
Andrey V. Savkin
3
Affiliations:
1
The University of New South Wales, Australia
;
2
Prince of Wales Hospital, and The University of New South Wales, Australia
;
3
University of New South Wales, Australia
Keyword(s):
Stroke volume variability (SVV), Systolic blood pressure variability (SBPV), Power spectral analysis, sympathovagal balance, Levosimendan, verapamil, Calcium channel sensitizers, Calcium channel blockers.
Related
Ontology
Subjects/Areas/Topics:
Applications and Services
;
Biomedical Engineering
;
Biomedical Signal Processing
;
Computer Vision, Visualization and Computer Graphics
;
Informatics in Control, Automation and Robotics
;
Medical Image Detection, Acquisition, Analysis and Processing
;
Signal Processing, Sensors, Systems Modeling and Control
;
Time and Frequency Response
;
Time-Frequency Analysis
Abstract:
This study presents results that describe the short term oscillations in SBPV and SVV signals due to calcium channel blockers poisoning with verapamil treated with continuous infusion of levosimendan. In addition, we used average spectra of these oscillations to observe the activity and sympathovagal balance of the autonomic nervous system. Then, we compared the average spectra obtained from both signals. The frequency contents of the average spectra of SVV and SBPV signals to levosimendan treatment of verapamil-poisoned rats were analyzed and related to the activity of sympathetic and parasympathetic tones. In control group, average spectra of SVV and SBPV exhibited a low-frequency band (LF: 0.03−0.8 Hz) peaked at ~ 0.4 Hz and a highfrequency (HF: 0.8−3.0 Hz) peaked at ~ 1 Hz. LF peak was abolished after verapamil infusion. The LF component of both spectra was observed to recover after continuous infusion of levosimendan. Additionally, a new frequency component was observed at 1.5 H
z in the spectrum of SBPV. Significant correlations were found between bands of the average spectra in both signals in all groups of treatment studied in this paper. Our results revealed that, like SBPV, SVV can herald useful information regarding the sympathovagal balance and cardiac output improvements.
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