The Renal Protective Potential Effect of Infusion of Anti-urolithiasis Formula in Urolithiasis Patients: A Randomized Clinical Study

Ulfatun Nisa, Peristiwan Ridha Widhi Astana, Saryanto, Tyas Friska Dewi, Enggar Wijayanti

2020

Abstract

Kidney stones and related urological procedures can lead to chronic kidney disease (CKD). The constituent plants of an anti-urolithiasis formula developed by B2P2TOOT have a potential renoprotective effect, thus preventing CKD progression. This randomized open-label clinical study with end-blinded observation was aimed to evaluate the possible renoprotective effect of anti-urolithiasis formula infusions in urolithiasis patients. Two hundred volunteer subjects were randomly allocated into two groups: anti-urolithiasis herbal formula (AHF) and commercial polyextract lithotripsy (CPL). Urine tests were performed, and the estimated glomerular filtration rate (eGFR) was calculated using a CKD-EPI equation at baseline (day 0) and after the intervention (day 56). The analysis was done within each group and between both groups using paired sample T-test and independent T-tests. An increase in the eGFR of subjects in the AHF group was found, although it was not statistically significant (p=0.35). The mean of the eGFR of subjects in the CPL group after the intervention was lower, also statistically insignificant (p=0.56). Nevertheless, there were significant differences in the eGFR after intervention between both groups (p=0.044, 95% CI 0.16–12.4). Our findings suggest that AHF has a slight potential effect on renal function preservation in urolithiasis patients.

Paper Citation

in Harvard Style

Nisa U., Widhi Astana P., Saryanto., Dewi T. and Wijayanti E. (2020). The Renal Protective Potential Effect of Infusion of Anti-urolithiasis Formula in Urolithiasis Patients: A Randomized Clinical Study.In Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC, ISBN 978-989-758-499-2, pages 91-97. DOI: 10.5220/0010488300910097

in Bibtex Style

@conference{jimc20,
author={Ulfatun Nisa and Peristiwan Ridha Widhi Astana and Saryanto and Tyas Friska Dewi and Enggar Wijayanti},
title={The Renal Protective Potential Effect of Infusion of Anti-urolithiasis Formula in Urolithiasis Patients: A Randomized Clinical Study},
booktitle={Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,},
year={2020},
pages={91-97},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010488300910097},
isbn={978-989-758-499-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st Jenderal Soedirman International Medical Conference in conjunction with the 5th Annual Scientific Meeting (Temilnas) Consortium of Biomedical Science Indonesia - Volume 1: JIMC,
TI - The Renal Protective Potential Effect of Infusion of Anti-urolithiasis Formula in Urolithiasis Patients: A Randomized Clinical Study
SN - 978-989-758-499-2
AU - Nisa U.
AU - Widhi Astana P.
AU - Saryanto.
AU - Dewi T.
AU - Wijayanti E.
PY - 2020
SP - 91
EP - 97
DO - 10.5220/0010488300910097