Late Diagnosis Merkel Cell Carcinoma with History of Basal Cell Carcinoma

Adelia Hanung Puspaningtyas, Lydia Kurniasari, Renni Yuniati, Buwono Puruhito, Puji Sriyani

2019

Abstract

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor. The etiopathogenetic remains unclear, associated with Merkel cell polyomavirus.MCC presents as an asymptomatic lesion or dome-shaped nodules that clinically benign. Diagnosis is based on histopathology and immunohistochemistry assay. This therapy includes excision, radiotherapy, immunotherapy, and chemotherapy. This case report is aimed to give more understanding of the diagnosis and management of MCC. A 47-year-old man presented with multiple pale-reddish tumors for eight months previously. Initially, the clinical feature was reddish, scaly, and dry patches spread over the extremities. The biopsy two years ago showed BCC. There was no regional lymph node involvement. Physical examination found verrucous tumors, with the largest size of 5 centimeters, erythematous macules, papules, erythematous plaques, crusts, and scales on the right elbow and leg. Excision was followed by split-thickness skin graft and chemotherapy. One month post-surgery, the patient had tetraparesis, and he died due to distant metastases one month later. The diagnosis of MCC was established on history, clinical, histopathological, and immunohistochemistry examinations.Sun exposure, elderly age, and fair-skin type are the major factors that can cause MCC. Patient sustains advanced stage and distant metastatic with a mortality rate between 33%- 46 %. MCC generally occurs on elderly fair-skinned men with high UV exposure and poor prognosis at an advanced stage.

Paper Citation

in Harvard Style

Puspaningtyas A., Kurniasari L., Yuniati R., Puruhito B. and Sriyani P. (2019). Late Diagnosis Merkel Cell Carcinoma with History of Basal Cell Carcinoma.In Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI, ISBN 978-989-758-469-5, pages 371-374. DOI: 10.5220/0009989203710374

in Bibtex Style

@conference{ictromi19,
author={Adelia Hanung Puspaningtyas and Lydia Kurniasari and Renni Yuniati and Buwono Puruhito and Puji Sriyani},
title={Late Diagnosis Merkel Cell Carcinoma with History of Basal Cell Carcinoma},
booktitle={Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,},
year={2019},
pages={371-374},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0009989203710374},
isbn={978-989-758-469-5},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease - Volume 1: ICTROMI,
TI - Late Diagnosis Merkel Cell Carcinoma with History of Basal Cell Carcinoma
SN - 978-989-758-469-5
AU - Puspaningtyas A.
AU - Kurniasari L.
AU - Yuniati R.
AU - Puruhito B.
AU - Sriyani P.
PY - 2019
SP - 371
EP - 374
DO - 10.5220/0009989203710374