Cytotoxic Carbazole Alkaloid from the Root of Clausena cxcavata on Hela Cell Line

Tin Myo Thant, Nanik Siti Aminah, Alfinda Novi Kristanti, Rico Ramadhan, Hnin Thanda Aung, Yoshiaki Takaya

2019

Abstract

In a searching for bioactive constituents from Myanmar medicinal plants, a carbazole alkaloid, named 7-hydroxy heptaphylline (1) was isolated from the root of Clausena excavata. The structure of isolated compound was elucidated based on spectrophotometric data such as UV-vis, FT-IR, NMR and HRMS data. The cytotoxicity of the isolated compound (1) was evaluated by MTT assay against on HeLa cancer cells. The compound (1) exhibited moderate inhibition activity with IC50 41.4 µg/ml.

Paper Citation

in Harvard Style

Thant T., Aminah N., Kristanti A., Ramadhan R., Aung H. and Takaya Y. (2019). Cytotoxic Carbazole Alkaloid from the Root of Clausena cxcavata on Hela Cell Line.In Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI, ISBN 978-989-758-415-2, pages 141-144. DOI: 10.5220/0008858101410144

in Bibtex Style

@conference{icocsti19,
author={Tin Myo Thant and Nanik Siti Aminah and Alfinda Novi Kristanti and Rico Ramadhan and Hnin Thanda Aung and Yoshiaki Takaya},
title={Cytotoxic Carbazole Alkaloid from the Root of Clausena cxcavata on Hela Cell Line},
booktitle={Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI,},
year={2019},
pages={141-144},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008858101410144},
isbn={978-989-758-415-2},
}

in EndNote Style

TY - CONF

JO - Proceedings of the 1st International Conference on Chemical Science and Technology Innovation - Volume 1: ICOCSTI,
TI - Cytotoxic Carbazole Alkaloid from the Root of Clausena cxcavata on Hela Cell Line
SN - 978-989-758-415-2
AU - Thant T.
AU - Aminah N.
AU - Kristanti A.
AU - Ramadhan R.
AU - Aung H.
AU - Takaya Y.
PY - 2019
SP - 141
EP - 144
DO - 10.5220/0008858101410144