Circadian Dynamics of High Frequency Oscillations in Patients with Epilepsy

Jirí Balach, Petr Jezdik, Radek Janca, Roman Cmejla, Pavel Krsek, Petr Marusic, Premysl Jiruska


High frequency oscillations (HFOs) are novel biomarker of epileptogenic tissue. HFOs are currently used to localize the seizure generating areas of the brain, delineate the resection and to monitor the disease activity. It is well established that spatiotemporal dynamics of HFOs can be modified by sleep-wake cycle. In this study we aimed to evaluate in detail circadian and ultradian changes in HFO dynamics using techniques of automatic HFO detection. For this purpose we have developed and implemented novel algorithm to automatic detection and analysis of HFOs in long-term intracranial recordings of six patients. In 5/6 patients HFO rates significantly increased during NREM sleep. The largest NREM related increase in HFO rates were observed in brain areas which spatially overlapped with seizure onset zone. Analysis of long-term recording revealed existence of ultradian changes in HFO dynamics. This study demonstrated reliability of automatic HFO detection in the analysis of long-term intracranial recordings in humans. Obtained results can foster practical implementation of automatic HFO detecting algorithms into presurgical examination, dramatically decrease human labour and increase the information yield of HFOs.


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Paper Citation

in Harvard Style

Balach J., Jezdik P., Janca R., Cmejla R., Krsek P., Marusic P. and Jiruska P. (2016). Circadian Dynamics of High Frequency Oscillations in Patients with Epilepsy . In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 4: BIOSIGNALS, (BIOSTEC 2016) ISBN 978-989-758-170-0, pages 284-289. DOI: 10.5220/0005827602840289

in Bibtex Style

author={Jirí Balach and Petr Jezdik and Radek Janca and Roman Cmejla and Pavel Krsek and Petr Marusic and Premysl Jiruska},
title={Circadian Dynamics of High Frequency Oscillations in Patients with Epilepsy},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 4: BIOSIGNALS, (BIOSTEC 2016)},

in EndNote Style

JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 4: BIOSIGNALS, (BIOSTEC 2016)
TI - Circadian Dynamics of High Frequency Oscillations in Patients with Epilepsy
SN - 978-989-758-170-0
AU - Balach J.
AU - Jezdik P.
AU - Janca R.
AU - Cmejla R.
AU - Krsek P.
AU - Marusic P.
AU - Jiruska P.
PY - 2016
SP - 284
EP - 289
DO - 10.5220/0005827602840289