Heritability Estimation Methods of Multiple Brain Measures: A Preliminary MRI Study in Twins

Yu Yong Choi, Kun Ho Lee

Abstract

Heritability is the proportion of total phenotypic variance due to genetic influence. To estimate heritability, Falconer’s method and structural equation modeling (SEM) are used. However, compared to Falconer’s formula, SEM is hardly applicable for neuroimaging analysis because the SEM tools such as Mx cannot calculate numerous data simultaneously nor sequentially. We developed a code for multiple calculations using Mx to estimate the heritability of gray matter thickness at 81,924 surface points across the cerebral cortex. Although FF and SEM provided similar results, SEM was inclined to yield lower heritability estimates and more conservative significance than Falconer’s method. In considering the results, we propose that the correction for multiple comparisons should be carefully performed for the results from SEM.

References

  1. Chung, M. K., Worsley, K. J., Robbins, S., Paus, T., Taylor, J., Giedd, J. N., et al. (2003). Deformation-based surface morphometry applied to gray matter deformation. Neuroimage, 18(2), 198-213.
  2. Collins, D. L., Neelin, P., Peters, T. M., & Evans, A. C. (1994). Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr, 18(2), 192-205.
  3. Falconer, D. S., & MacKay, T. F. C. (1996). Introduction to Quantitative Genetics (4th ed.). Harlow, Essex, UK: Longman.
  4. Ihaka, R., & Gentleman, R. (1996). R: A Language for Data Analysis and Graphics. Journal of Computational and Graphical Statistics, 5(3), 299-314.
  5. Kabani, N., Le Goualher, G., MacDonald, D., & Evans, A. C. (2001). Measurement of cortical thickness using an automated 3-D algorithm: a validation study. Neuroimage, 13(2), 375-380.
  6. Kim, J. S., Singh, V., Lee, J. K., Lerch, J., Ad-Dab'bagh, Y., MacDonald, D., et al. (2005). Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification. NeuroImage, 27(1), 210-221.
  7. Koten, J. W., Jr., Wood, G., Hagoort, P., Goebel, R., Propping, P., Willmes, K., et al. (2009). Genetic contribution to variation in cognitive function: an FMRI study in twins. Science, 323(5922), 1737-1740.
  8. MacDonald, D., Kabani, N., Avis, D., & Evans, A. C. (2000). Automated 3-D extraction of inner and outer surfaces of cerebral cortex from MRI. NeuroImage, 12(3), 340-356.
  9. Neale, M. C., Boker, S. M., Xie, G., & Maes, H. H. (2003). Mx: Statistical Modeling (6th ed.). VCU Box 900126, Richmond, VA 23298: Department of Psychiatry.
  10. Sled, J. G., Zijdenbos, A. P., & Evans, A. C. (1998). A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging, 17(1), 87-97.
  11. Zijdenbos, A. P., Forghani, R., & Evans, A. C. (2002). Automatic "pipeline" analysis of 3- D MRI data for clinical trials: application to multiple sclerosis. IEEE Trans Med Imaging, 21(10), 1280-1291.
Download


Paper Citation


in Harvard Style

Choi Y. and Lee K. (2011). Heritability Estimation Methods of Multiple Brain Measures: A Preliminary MRI Study in Twins . In Proceedings of the 2nd International Workshop on Medical Image Analysis and Description for Diagnosis Systems - Volume 1: MIAD, (BIOSTEC 2011) ISBN 978-989-8425-38-6, pages 82-87. DOI: 10.5220/0003305100820087


in Bibtex Style

@conference{miad11,
author={Yu Yong Choi and Kun Ho Lee},
title={Heritability Estimation Methods of Multiple Brain Measures: A Preliminary MRI Study in Twins },
booktitle={Proceedings of the 2nd International Workshop on Medical Image Analysis and Description for Diagnosis Systems - Volume 1: MIAD, (BIOSTEC 2011)},
year={2011},
pages={82-87},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003305100820087},
isbn={978-989-8425-38-6},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 2nd International Workshop on Medical Image Analysis and Description for Diagnosis Systems - Volume 1: MIAD, (BIOSTEC 2011)
TI - Heritability Estimation Methods of Multiple Brain Measures: A Preliminary MRI Study in Twins
SN - 978-989-8425-38-6
AU - Choi Y.
AU - Lee K.
PY - 2011
SP - 82
EP - 87
DO - 10.5220/0003305100820087