USING GRANGER CAUSALITY TO CHARACTERISE BIDIRECTIONAL INTERACTIONS IN THE HUMAN BRAIN DURING INDUCTION OF ANAESTHESIA

Nicoletta Nicolaou, Julius Georgiou, Saverios Houris, Pandelitsa Alexandrou

Abstract

General anaesthesia is a reversible state whereby conscious experience is disrupted and reflexes to afferent stimuli are depressed. The precise method of action of anaesthetic agents is still largely unknown. However, the administration of anaesthetics causes observable changes in the electrical brain activity (EEG), the study of which can provide an insight into the mechanism of action of general anaesthesia. This paper investigates the patterns of bidirectional interactions that are manifest in brain activity during anaesthetic induction with propofol. Granger Causality is applied to the EEG of patients scheduled for surgery under general anaesthesia as a means of characterising the interactions between different brain areas prior and after the administration of the anaesthetic agents. Strong unidirectional information flow between frontal and posterior areas was found to occur shortly after anaesthetic induction.

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Paper Citation


in Harvard Style

Nicolaou N., Georgiou J., Houris S. and Alexandrou P. (2011). USING GRANGER CAUSALITY TO CHARACTERISE BIDIRECTIONAL INTERACTIONS IN THE HUMAN BRAIN DURING INDUCTION OF ANAESTHESIA . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011) ISBN 978-989-8425-35-5, pages 188-194. DOI: 10.5220/0003148601880194


in Bibtex Style

@conference{biosignals11,
author={Nicoletta Nicolaou and Julius Georgiou and Saverios Houris and Pandelitsa Alexandrou},
title={USING GRANGER CAUSALITY TO CHARACTERISE BIDIRECTIONAL INTERACTIONS IN THE HUMAN BRAIN DURING INDUCTION OF ANAESTHESIA},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011)},
year={2011},
pages={188-194},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003148601880194},
isbn={978-989-8425-35-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011)
TI - USING GRANGER CAUSALITY TO CHARACTERISE BIDIRECTIONAL INTERACTIONS IN THE HUMAN BRAIN DURING INDUCTION OF ANAESTHESIA
SN - 978-989-8425-35-5
AU - Nicolaou N.
AU - Georgiou J.
AU - Houris S.
AU - Alexandrou P.
PY - 2011
SP - 188
EP - 194
DO - 10.5220/0003148601880194