HEART RATE VARIABILITY ANALYSIS OF CHILDREN WITH REFRACTORY EPILEPSY BEFORE AND AFTER THE VAGUS NERVE STIMULATION

Milica Milošević, Steven Vandeput, Sabine Van Huffel, Katrien Jansen, Lieven Lagae

Abstract

Vagus nerve stimulation (VNS) is a well-known therapeutic option for patients with refractory epilepsy who do not respond to adequate anti-epileptic drugs. Heart rate variability (HRV) is mediated by sympathetic and parasympathetic efferent activities which always interact towards the heart. Our goal was to describe the link between autonomic nervous system (ANS) and HRV. In 18 epileptic children, ECG data were obtained before and after implantation of the VNS. HRV was measured by linear and nonlinear parameters during 50 minute epochs during phase 2 of sleep and deep sleep. Results of the patients were compared with those of an age and sex matched control group. We were able to confirm that vagus nerve stimulation do not influence heart rate in children with refractory epilepsy. After the VNS implantation, there is a shift in sympathovagal balance towards sympathetic predominance in phase 2 of sleep (p=0.177) and also during deep sleep (p=0.035). This study suggests that left vagus nerve stimulation has little effect on heart rate variability as measured by nonlinear parameters.

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Paper Citation


in Harvard Style

Milošević M., Vandeput S., Van Huffel S., Jansen K. and Lagae L. (2011). HEART RATE VARIABILITY ANALYSIS OF CHILDREN WITH REFRACTORY EPILEPSY BEFORE AND AFTER THE VAGUS NERVE STIMULATION . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011) ISBN 978-989-8425-35-5, pages 409-412. DOI: 10.5220/0003132504090412


in Bibtex Style

@conference{biosignals11,
author={Milica Milošević and Steven Vandeput and Sabine Van Huffel and Katrien Jansen and Lieven Lagae},
title={HEART RATE VARIABILITY ANALYSIS OF CHILDREN WITH REFRACTORY EPILEPSY BEFORE AND AFTER THE VAGUS NERVE STIMULATION},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011)},
year={2011},
pages={409-412},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003132504090412},
isbn={978-989-8425-35-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011)
TI - HEART RATE VARIABILITY ANALYSIS OF CHILDREN WITH REFRACTORY EPILEPSY BEFORE AND AFTER THE VAGUS NERVE STIMULATION
SN - 978-989-8425-35-5
AU - Milošević M.
AU - Vandeput S.
AU - Van Huffel S.
AU - Jansen K.
AU - Lagae L.
PY - 2011
SP - 409
EP - 412
DO - 10.5220/0003132504090412