SYNCHRONISATION OF BIOLOGICAL CLOCK SIGNALS - Capturing Coupled Repressilators from a Control Systems Perspective

Thomas Hinze, Mathias Schumann, Stefan Schuster

Abstract

Exploration of chronobiological systems emerges as a growing research field within bioinformatics focusing on various applications in medicine, agriculture, and material sciences. From a systems biological perspective, the question arises whether biological control systems for regulation of oscillative signals and their technical counterparts utilise similar mechanisms. If so, modelling approaches and parameterisation adopted from building blocks can help to identify general components for clock synchronisation. Phase-locked loops could be an interesting candidate in this context. Both, biology and engineering, can benefit from a unified view. In a first experimental study, we analyse a model of coupled repressilators. We demonstrate its ability to synchronise clock signals in a monofrequential manner. Several oscillators initially deviate in phase difference and frequency with respect to explicit reaction and diffusion rates. Accordingly, the duration of the synchronisation process depends on dedicated reaction and diffusion parameters whose settings still lack to be sufficiently captured by comprehensive tools like the Kuramoto approach.

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Paper Citation


in Harvard Style

Hinze T., Schumann M. and Schuster S. (2011). SYNCHRONISATION OF BIOLOGICAL CLOCK SIGNALS - Capturing Coupled Repressilators from a Control Systems Perspective . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011) ISBN 978-989-8425-35-5, pages 101-106. DOI: 10.5220/0003121301010106


in Bibtex Style

@conference{biosignals11,
author={Thomas Hinze and Mathias Schumann and Stefan Schuster},
title={SYNCHRONISATION OF BIOLOGICAL CLOCK SIGNALS - Capturing Coupled Repressilators from a Control Systems Perspective},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011)},
year={2011},
pages={101-106},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003121301010106},
isbn={978-989-8425-35-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011)
TI - SYNCHRONISATION OF BIOLOGICAL CLOCK SIGNALS - Capturing Coupled Repressilators from a Control Systems Perspective
SN - 978-989-8425-35-5
AU - Hinze T.
AU - Schumann M.
AU - Schuster S.
PY - 2011
SP - 101
EP - 106
DO - 10.5220/0003121301010106