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Centro de Biomateriales, Universidad Politécnica de Valencia; Regenerative Medicine Unit, Centro de Investigación Príncipe Felipe; CIBER en Bioingeniería, Biomateriales y Nanomedicina

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2 Papers

BIOREACTOR FOR MECHANICAL CELL STIMULATION - Concept and Design

Topics: Biomedical Instrumentation; Biomedical Sensors; Transducers and Packaging

Authors: J. G. Rocha ¹ , V. Correia ¹ , J. L. Gomez Ribelles ² , S. Lanceros-Mendez ¹ and A. Pitaes ¹

Affiliations: ¹ University of Minho, Portugal , ² Centro de Biomateriales, Universidad Politécnica de Valencia; Regenerative Medicine Unit, Centro de Investigación Príncipe Felipe; CIBER en Bioingeniería, Biomateriales y Nanomedicina, Spain

Digital Object Identifier: 10.5220/0002759401470151

Proceedings of BIODEVICES 2010/BIOSTEC, ISBN: 978-989-674-017-7

Quick Abstract

Mechanical stimulation plays an important role in improving cell growth in the skeletal system, for example. In this article we describe a bioreactor in which cells in a three-dimensional scaffolds are stimulated by cyclically applied mechanical loads. The objective of this study is to develop a custom-designed bioreactor capable of applying controlled compressive loads to a cell-encapsulating scaffold. Its working principle is based on an innovative design of a feedback controlled electromagnetic actuator, which allows the application of compressive forces to the samples and at the same time, it allows the measurement of the produced displacement.

Related Ontology Subjects/Areas/Topics (5)

Biomedical Engineering		Biomedical Instruments and Devices		Transducers and Packaging
Biomedical Instrumentation		Biomedical Sensors

THE ROLE OF THREE-DIMENSIONAL SCAFFOLDS IN THE REGENERATION OF JOINT CARTILAGE

Authors: J. L. Gómez Ribelles ¹ , M. Monleón Pradas ¹ , R. García Gómez ² , F. Forriol ³ , M. Sancho-Tello ³ and C. Carda ⁴

Affiliations: ¹ Centro de Biomateriales e Ingeniería Tisular, Universidad Politécnica de Valencia; Regenerative Medicine Unit, Centro de Investigación Príncipe Felipe; CIBER en Bioingeniería, Biomateriales y Nanomedicina, Spain , ² Regenerative Medicine Unit, Centro de Investigación Príncipe Felipe, Spain , ³ Universidad de Valencia, Spain , ⁴ Universsidad de Valencia, Spain

Digital Object Identifier: 10.5220/0002765102290234

Proceedings of Special Session RAPID-Bio 2010/BIOSTEC, ISBN: 978-989-674-017-7

Quick Abstract

A variety of polymer scaffolds with pore architecture consisting of interconnected spherical pores with the same architecture but varying mechanical properties (in particular elastic modulus), water sorption capacity, pore surface characteristics (surface tension, presence of hydrophilic groups or electric charges) was prepared and implanted in a 3mm diameter full thickness defects in the knee joint cartilage of rabbits in order to show the influence of the scaffold properties on the histological characteristics of the regenerated tissue.