Study on the Fidelity of Biodevice T7 DNA Polymerase

Ming Li, Zhong-Can Ou-Yang, Yao-Gen Shu

Abstract

We proposed a comprehensive kinetic model of steady-state copolymerization and obtain analytical solution of the high replication fidelity of the biodevice DNA polymerase. Our analytical calculations definitively show that the neighbor effects are the key factor of the overall fidelity. These analytical results were further demonstrated by T7 DNAp whose fidelity (106) is well described by the 1st-order neighbor effect.

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Paper Citation


in Harvard Style

Li M., Ou-Yang Z. and Shu Y. (2018). Study on the Fidelity of Biodevice T7 DNA Polymerase.In Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 4: BIOINFORMATICS, ISBN 978-989-758-280-6, pages 135-139. DOI: 10.5220/0006636101350139


in Bibtex Style

@conference{bioinformatics18,
author={Ming Li and Zhong-Can Ou-Yang and Yao-Gen Shu},
title={Study on the Fidelity of Biodevice T7 DNA Polymerase},
booktitle={Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 4: BIOINFORMATICS,},
year={2018},
pages={135-139},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006636101350139},
isbn={978-989-758-280-6},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 4: BIOINFORMATICS,
TI - Study on the Fidelity of Biodevice T7 DNA Polymerase
SN - 978-989-758-280-6
AU - Li M.
AU - Ou-Yang Z.
AU - Shu Y.
PY - 2018
SP - 135
EP - 139
DO - 10.5220/0006636101350139