Test Device for Blood Transfusion Safety - How Acoustics Can Help Preventing Any Red Cells Incompatibility

Karine Charrière, Jean-Francois Manceau, Pascal Morel, Véronique Bourcier, Wilfrid Boireau, Lionel Pazart, Bruno Wacogne

Abstract

During red cells concentrates transfusion, red cells incompatibilities still occur despite the laboratory controls based on immuno-hematologic techniques. Red cells incompatibilities appear when patient’s antibodies bind to red cells to be transfused. Up to now, all pre-transfusion testing are addressed using techniques based on immunology. This is time consuming, expensive and some incompatibility situations cannot be addressed at the patient’s bedside. In this position paper, we propose a completely novel paradigm. Our hypothesis is that red blood cells sensitized by the patient’s antibodies see their deformability greatly reduced. This induces changes of the rheological properties of the “red cells concentrate /patient’s blood” mixture. Studies described in this position paper aim at characterizing these modifications by measuring the characteristics of acoustic waves propagating in the mixture and to produce a mobile and automated acousto-micro-fluidic device which would allow detecting any incompatibility at the patient’s bed side.

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Paper Citation


in Harvard Style

Charrière K., Manceau J., Morel P., Bourcier V., Boireau W., Pazart L. and Wacogne B. (2018). Test Device for Blood Transfusion Safety - How Acoustics Can Help Preventing Any Red Cells Incompatibility.In Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, ISBN 978-989-758-277-6, pages 206-211. DOI: 10.5220/0006635702060211


in Bibtex Style

@conference{biodevices18,
author={Karine Charrière and Jean-Francois Manceau and Pascal Morel and Véronique Bourcier and Wilfrid Boireau and Lionel Pazart and Bruno Wacogne},
title={Test Device for Blood Transfusion Safety - How Acoustics Can Help Preventing Any Red Cells Incompatibility},
booktitle={Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES,},
year={2018},
pages={206-211},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006635702060211},
isbn={978-989-758-277-6},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES,
TI - Test Device for Blood Transfusion Safety - How Acoustics Can Help Preventing Any Red Cells Incompatibility
SN - 978-989-758-277-6
AU - Charrière K.
AU - Manceau J.
AU - Morel P.
AU - Bourcier V.
AU - Boireau W.
AU - Pazart L.
AU - Wacogne B.
PY - 2018
SP - 206
EP - 211
DO - 10.5220/0006635702060211