Optimising Graphical Techniques Applied to Irreversible Tracers

Yasser Alzamil, Yulia Hicks, Xin Yang, Christopher Marshall

Abstract

Graphical analysis techniques are often applied to positron emission tomography (PET) images to estimate physiological parameters. Patlak analysis is primarily used to obtain the rate constant (Ki) that indicates the transfer of a tracer from plasma to the irreversible compartment and ultimately describes how the tracer binds to the targeted tissue. One of the most common issues associated with Patlak analysis is the introduction of statistical noise that affects the slope of the graphical plot and causes bias. In this study, several statistical methods are proposed and applied to PET time activity curves (TACs) for both reversible and irreversible regions that are involved in the equation. A dynamic PET imaging simulator for the Patlak model was used to evaluate the statistical methods employed to reduce the bias introduced in the acquired data.

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Paper Citation


in Harvard Style

Alzamil Y., Hicks Y., Yang X. and Marshall C. (2018). Optimising Graphical Techniques Applied to Irreversible Tracers .In Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 2: BIOIMAGING, ISBN 978-989-758-278-3, pages 17-26. DOI: 10.5220/0006513700170026


in Bibtex Style

@conference{bioimaging18,
author={Yasser Alzamil and Yulia Hicks and Xin Yang and Christopher Marshall},
title={Optimising Graphical Techniques Applied to Irreversible Tracers },
booktitle={Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 2: BIOIMAGING,},
year={2018},
pages={17-26},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006513700170026},
isbn={978-989-758-278-3},
}


in EndNote Style

TY - CONF

JO - Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 2: BIOIMAGING,
TI - Optimising Graphical Techniques Applied to Irreversible Tracers
SN - 978-989-758-278-3
AU - Alzamil Y.
AU - Hicks Y.
AU - Yang X.
AU - Marshall C.
PY - 2018
SP - 17
EP - 26
DO - 10.5220/0006513700170026