Biological Network Modelling and Pathway Analysis

Ansam Al-Sabti, Mohamed Zaibi, Sabah Jassim

Abstract

ABSTRACT The search for disease-specific biomarkers for di- agnosis, illness monitoring, therapy evaluation, and, prognosis prediction is one of the major challenges in biomedical research. It has long been that diseases are rarely caused by abnormality in a single protein, gene or cell. But by disorder of different processes man- ifested by intracellular network of interactions be- tween the molecular components in such biological systems. Despite the popularity of biological network anal- ysis methods and increasing use for identifying genes or pathways (groups of genes) that contribute to diseases and other biological processes, impor- tant topological and network information are hardly used in ranking/assessing the relevance of the path- ways. Often, gene expression values and confidence score/strength of interactions are not considered when scoring/ranking the resulting pathways. The research presented in this paper focuses on two different, but closely related areas in Bioinfor- matics: developing new approaches for biological network analysis, and improving the identification of disease biomarkers. The inclusion of topological weight and expression level in the calculation of path- ways score is expected to facilitate the identification of the pathways that most relevant to pathophysiolog- ical processes.

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Paper Citation


in Harvard Style

Al-Sabti A., Zaibi M. and Jassim S. (2017). Biological Network Modelling and Pathway Analysis . In Doctoral Consortium - DCBIOSTEC, (BIOSTEC 2017) ISBN , pages 16-25


in Bibtex Style

@conference{dcbiostec17,
author={Ansam Al-Sabti and Mohamed Zaibi and Sabah Jassim},
title={Biological Network Modelling and Pathway Analysis},
booktitle={Doctoral Consortium - DCBIOSTEC, (BIOSTEC 2017)},
year={2017},
pages={16-25},
publisher={SciTePress},
organization={INSTICC},
doi={},
isbn={},
}


in EndNote Style

TY - CONF
JO - Doctoral Consortium - DCBIOSTEC, (BIOSTEC 2017)
TI - Biological Network Modelling and Pathway Analysis
SN -
AU - Al-Sabti A.
AU - Zaibi M.
AU - Jassim S.
PY - 2017
SP - 16
EP - 25
DO -