Layer-by-layer Assembled Films for Ocular Drug Delivery

Mónica Araújo, Jorge Morgado, Quirina Ferreira

Abstract

In this paper we describe a simple and versatile method to prepare drug delivery films composed of an ocular drug used in glaucoma treatment, brimonidine, which was encapsulated in a polymer-beta cyclodextrin. The films were developed in order to allow a controlled sequential release during long periods of time. Here we show that by introducing barrier layers of graphene oxide between the drug delivery ones it is possible to delay the brimonidine release for a few days. The time interval between two dosages of drug release will be controlled by adjusting the number and/or thickness of the graphene layers.

References

  1. Bosch-Navarro, C., Coronado, E., Martí-Gastaldo, C., Sánchez-Royo, J. F., and G ómez, M. G. (2012). Influence of the ph on the synthesis of reduced graphene oxide under hydrothermal conditions. Nanoscale, 4(13):3977.
  2. Choi, W., Choi, J., Bang, J., and Lee, J. H. (2013). Layerby-layer assembly of graphene oxide nanosheets on polyamide membranes for durable reverse-osmosis applications. ACS Applied Materials and Interfaces, 5(23):12510-12519.
  3. Decher, G., Hong, J., and Schmitt, J. (1992). Buildup of ultrathin multilayer films by a self-assembly process: Iii. consecutively alternating adsorption of anionic and cationic polyelectrolytes on charged surfaces. Thin Solid Films, 210-211:831-835.
  4. Deng, X., Zheng, N., Song, Z., Yin, L., and Cheng, J. (2014). Trigger-responsive, fast-degradable poly(ß- amino ester)s for enhanced dna unpackaging and reduced toxicity. Biomaterials, 35(18):5006-5015.
  5. Enscore, D., Hopfenberg, H., Stannett, V., and Berens, A. (1977). Effect of prior sample history on n-hexane sorption in glassy polystyrene microspheres. Polymer, 18(11):1105-1110.
  6. European Glaucoma Society (2014). Terminolology and guidelines for glaucoma. European Glaucoma Society, 4th edition edition.
  7. Ferreira, Q., Braganca, A. M., Alcacer, L., and Morgado, J. (2014). Conductance of well-defined porphyrin selfassembled molecular wires up to 14 nm in length. Journal of Physical Chemistry C, 118(13):7229-7234.
  8. Ferreira, Q., Gomes, P., Maneira, M., Ribeiro, P., and Raposo, M. (2007). Mechanisms of adsorption of an azopolyelectrolyte onto layer-by-layer films. Sensors and Actuators B: Chemical, 126(1):311-317.
  9. Ferreira, Q., Ribeiro, P. A., Oliveira, O. N., and Raposo, M. (2012). Long-term stability at high temperatures for birefringence in pazo/pah layer-by-layer films. ACS Applied Materials & Interfaces, 4(3):1470-1477.
  10. Fick, A. (1995). On liquid diffusion. Journal of Membrane Science, 100(1):33-38.
  11. Halász, K., Hosakun, Y., and Cs óka, L. (2015). Reducing water vapor permeability of poly(lactic acid) film and bottle through layer-by-layer deposition of greenprocessed cellulose nanocrystals and chitosan. International Journal of Polymer Science, 2015:1-6.
  12. Holowka, E. P. and Bhatia, S. K. (2014). Drug Delivery, volume 197 of Handbook of Experimental Pharmacology. Springer New York.
  13. Hong, J., Shah, N. J., Drake, A. C., DeMuth, P. C., Lee, J. B., Chen, J., and Hammond, P. T. (2012). Graphene multilayers as gates for multi-week sequential release of proteins from surfaces. ACS Nano, 6(1):81-88.
  14. Hwang, H., Joo, P., Kang, M. S., Ahn, G., Han, J. T., Kim, B.-S., and Cho, J. H. (2012). Highly tunable charge transport in layer-by-layer assembled graphene transistors. ACS Nano, 6(3):2432-2440.
  15. Leita˜o, P., Amaral, A., Pinto, L. A., Ferreira, J., Magric¸o, A., Trinca˜o, F., Silva, J. P., and M., R. (2010). Avaliac¸a˜o do Conhecimento , Adesa˜o Terapeˆutica e Repercussa˜o de uma Sessa˜o Educativa sobre o Glaucoma numa Populac¸a˜o de Doentes seguidos na Consulta de Especialidade num Hospital Central. Oftalmologia, 34:295 - 300.
  16. Lynn, D. M. and Langer, R. (2000). Degradable poly (beta-amino esters ): Synthesis , characterization , and self-assembly with plasmid dna. J Am Chem Soc, 122(10):10761-10768.
  17. Macdonald, M., Rodriguez, N. M., Smith, R., and Hammond, P. T. (2008). Release of a model protein from biodegradable self assembled films for surface delivery applications. Journal of Controlled Release, 131(3):228-234.
  18. Nordstrom, B. L., Friedman, D. S., Mozaffari, E., Quigley, H. A., and Walker, A. M. (2005). Persistence and Adherence With Topical Glaucoma Therapy. American Journal of Ophthalmology, 140(4):598.e1-598.e11.
  19. Oliveira, O.N.Jr.; He, J.-A.; Zucolotto, V.; Balasubramanian, S.; Li, L.; Nalwa, H.S.; Kumar, J.; Tripathy, S. (2002). Layer-by-layer polyelectrolyte-based thin films for electronic and photonic applications. Handbook of Polyelectrolytes and Their Applications, 1:1- 38.
  20. Raposo, M. and Oliveira, O. N. (2000). Energies of adsorption of poly( o -methoxyaniline) layer-by-layer films. Langmuir, 16(6):2839-2844.
  21. Ritger, P. L. and Peppas, N. A. (1987). A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. Journal of Controlled Release, 5(1):37-42.
  22. Seo, J., Lutkenhaus, J. L., Kim, J., Hammond, P. T., and Char, K. (2008). Effect of the layer-by-layer (lbl) deposition method on the surface morphology and wetting behavior of hydrophobically modified peo and paa lbl films. Langmuir, 24(15):7995-8000.
  23. Siegel, R. A. and Rathbone, M. J. (2012). Fundamentals and Applications of Controlled Release Drug Delivery. Springer US, Boston, MA.
  24. Smith, R. C. (2010). Toward a Drug Delivery Coating for Intraocular. PhD thesis, University of North Carolina - Massachussets Institute of Technology.
  25. Tang, Z., Wang, Y., Podsiadlo, P., and Kotov, N. A. (2006). Biomedical applications of layer-by-layer assembly: From biomimetics to tissue engineering. Advanced Materials, 18(24):3203-3224.
  26. Zugates, G. T., Tedford, N. C., Zumbuehl, A., Jhunjhunwala, S., Kang, C. S., Griffith, L. G., Lauffenburger, D. a., Langer, R., and Anderson, D. G. (2007). Gene delivery properties of end-modified poly(beta-amino ester)s. Bioconjugate chemistry, 18(6):1887-1896.
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Paper Citation


in Harvard Style

Araújo M., Morgado J. and Ferreira Q. (2017). Layer-by-layer Assembled Films for Ocular Drug Delivery . In Proceedings of the 5th International Conference on Photonics, Optics and Laser Technology - Volume 1: BONano, (PHOTOPTICS 2017) ISBN 978-989-758-223-3, pages 395-401. DOI: 10.5220/0006320503950401


in Bibtex Style

@conference{bonano17,
author={Mónica Araújo and Jorge Morgado and Quirina Ferreira},
title={Layer-by-layer Assembled Films for Ocular Drug Delivery},
booktitle={Proceedings of the 5th International Conference on Photonics, Optics and Laser Technology - Volume 1: BONano, (PHOTOPTICS 2017)},
year={2017},
pages={395-401},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006320503950401},
isbn={978-989-758-223-3},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 5th International Conference on Photonics, Optics and Laser Technology - Volume 1: BONano, (PHOTOPTICS 2017)
TI - Layer-by-layer Assembled Films for Ocular Drug Delivery
SN - 978-989-758-223-3
AU - Araújo M.
AU - Morgado J.
AU - Ferreira Q.
PY - 2017
SP - 395
EP - 401
DO - 10.5220/0006320503950401