A CMOS Tracking System Approach for Cell Motility Assays

Cristina Martínez-Gómez, Alberto Olmo, Gloria Huertas, Pablo Pérez, Andres Maldonado-Jacobi, Alberto Yúfera

Abstract

This work proposes a method for studying and monitoring in real-time a single cell on a 2D electrode matrix, of great interest in cell motility assays and in the characterization of cancer cell metastasis. A CMOS system proposal for cell location based on occupation maps data generated from Electrical Cell-substrate Impedance Spectroscopy (ECIS) has been developed. From this cell model, obtained from experimental assays data, an algorithm based on analysis of the 8 nearest neighbors has been implemented, allowing the evaluation of the cell center of mass. The path followed by a cell, proposing a Brownian route, has been simulated with the proposed algorithm. The presented results show the success of the approach, with accuracy over 95% in the determination of any coordinate (x, y) from the expected center of mass.

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Paper Citation


in Harvard Style

Martínez-Gómez C., Olmo A., Huertas G., Pérez P., Maldonado-Jacobi A. and Yúfera A. (2017). A CMOS Tracking System Approach for Cell Motility Assays . In Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2017) ISBN 978-989-758-216-5, pages 229-236. DOI: 10.5220/0006291502290236


in Bibtex Style

@conference{biodevices17,
author={Cristina Martínez-Gómez and Alberto Olmo and Gloria Huertas and Pablo Pérez and Andres Maldonado-Jacobi and Alberto Yúfera},
title={A CMOS Tracking System Approach for Cell Motility Assays},
booktitle={Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2017)},
year={2017},
pages={229-236},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006291502290236},
isbn={978-989-758-216-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2017)
TI - A CMOS Tracking System Approach for Cell Motility Assays
SN - 978-989-758-216-5
AU - Martínez-Gómez C.
AU - Olmo A.
AU - Huertas G.
AU - Pérez P.
AU - Maldonado-Jacobi A.
AU - Yúfera A.
PY - 2017
SP - 229
EP - 236
DO - 10.5220/0006291502290236