A Qualitative Framework Dedicated to Toxicology

Benjamin Miraglio, Gilles Bernot, Jean-Paul Comet, Christine Risso-de Faverney

Abstract

Emerging constraints have led the toxicology community to complete the classical paradigm of toxicology with the study of molecular events underlying the toxicity of a chemical substance. This evolution motivates the emergence of new modelling approaches for toxicology. In this article, we introduce a qualitative rulebased formalism dedicated to the domain of toxicology. This new formalism departs from other rule-based formalisms such as BioChAM because it directly encodes possible alterations of equilibrium, instead of making equilibriums emerge from the dynamics of the model. Using a simple example of the energy metabolism, we show that this formalism is able to describe both the normal evolution of a biological system and its possible toxic disruptions.

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Paper Citation


in Harvard Style

Miraglio B., Bernot G., Comet J. and Risso-de Faverney C. (2017). A Qualitative Framework Dedicated to Toxicology . In Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2017) ISBN 978-989-758-214-1, pages 93-103. DOI: 10.5220/0006168200930103


in Bibtex Style

@conference{bioinformatics17,
author={Benjamin Miraglio and Gilles Bernot and Jean-Paul Comet and Christine Risso-de Faverney},
title={A Qualitative Framework Dedicated to Toxicology},
booktitle={Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2017)},
year={2017},
pages={93-103},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006168200930103},
isbn={978-989-758-214-1},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2017)
TI - A Qualitative Framework Dedicated to Toxicology
SN - 978-989-758-214-1
AU - Miraglio B.
AU - Bernot G.
AU - Comet J.
AU - Risso-de Faverney C.
PY - 2017
SP - 93
EP - 103
DO - 10.5220/0006168200930103