Radio Frequency CMOS Chem-bio Viscosity Sensors based on Dielectric Spectroscopy

Subhajit Guha, Christian Wenger

Abstract

This paper presents a CMOS Radio frequency dielectric sensor platform for the detection of relative viscosity changes in a fluid sample. The operating frequency of the sensor is 12.28 GHz. This frequency range has been chosen for high signal to noise ratio and also to avoid other low frequency dispersion mechanisms for future lab on chip applications. The sensor chip has been fabricated in 250 nm BiCMOS technology of IHP. The measurements conducted to show the relative viscosity variation detection capability of the sensor chip, were based on mixtures of glycerol and water as well as glycerol and organic alcohol. The detection limit of viscosity is dependent on the permittivity contrast of the sample constituent. Therefore, it is also shown the choice of frequency inherently aids in the permittivity contrast of the sample constituents.

References

  1. Agoston, A., Otsch, C., Jakoby, B., 2005. Viscosity sensors for engine oil condition monitoring-Application and interpretation of results. Sensors and Actuators A: Physical. 121 (2), 327-332.
  2. Torres Perez, A., Hadfield, M., 2011. Low-cost oil quality sensor based on changes in complex permittivity. Sensors. 11, 10675-10690.
  3. Thalhammer, R., Braun, S., Devicic-Kuhar, B., Groschl, M., Trampler, F., Benes, E., Nowotny, H., Kostal, M. 1998. Viscosity sensor utilizing a piezoelectric thickness shear sandwich resonator. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control. 45 (5), 1331-1340.
  4. Shih, W., Li, X., Gu, H., Shih, W-H., Aksay, I. 2001. Simultaneous liquid viscosity and density determination with piezoelectric unimorph cantilevers. Journal of Applied Physics. 89(2), 1497-1505.
  5. Brouwer, M., Gupta, L., Sadegi, F., Peroulis, D., Adams, D. 2011. High temperature dynamic viscosity sensor for engine oil applications. Sensors and Actuator A: Physical. 173, 102-107.
  6. Boss, C., Meurville, E., Sallese, J.M., Ryser, P. 2011. A viscosity-dependent affinity sensor for continuous monitoring of glucose in biological fluids. Biosensors and Bioelectronics, 30 (1), 223-228.
  7. Zhao, Y., Li, S., Davidson, A., Yang, B., Wang, Q., Lin, Q. 2007. A MEMS viscometric sensor for continuous glucose monitoring. Journal of Micromechanics and Microengineering. 17, 2528-2537.
  8. Cakmak, O., Ermek, E., Kilinc, N., Baris, I., Kavakli, I.J., Yaralioglu, G.G., Urey, H. 2014. Microcantilever based LOC system for coagulation measurements. In Proceedings, 18th International Conference on Miniaturized systems for chemistry and Life Sciences, Texas, USA.
  9. Guha, S, Wolf, A., Lisker, M., Trusch, A., Meliani, C., Wenger, Ch. 2015. 12 GHz CMOS MEMS lab-on-chip system for detection of concentration of suspended particles in bio-suspensions. In Proceedings, Biodevices, Lisbon, Portugal.
  10. Guha, S., Warsinke, A., Tientcheu, Ch.M., Schamlz, K., Meliani, C., Wenger, Ch. 2015. Label free sensing of creatinine using 6 GHz CMOS near-field dielectric immunosensor. Analyst 140, 3019-3027.
  11. Jamal, F.I., Guha, S., Eissa, M.H., Borngraeber, J., Meliani, C., Kissinger, D., Wessel, J. 2016. Comparison of microstrip stub resonators for dielectric sensing in low power K-Band VCO. In Proceedings IEEE Topical Conference on Biomedical Wireless Technologies, Networks and Sensing, Texas, USA.
  12. Wang, H., Sideris, C., Hajimiri, A. 2010. A frequency shift based CMOS magnetic biosensor with spatially uniform sensor transducer gain., IEEE; Custom Integrated Circuit Conference, USA.
  13. Lopez-Vidriero, M., Charman, J., Keal, E., De Silva, D., and L Reid, L. 1973. Sputum viscosity: correlation with chemical and clinical features in chronic bronchitis. Thorax, 28, 401- 408.
Download


Paper Citation


in Harvard Style

Guha S. and Wenger C. (2017). Radio Frequency CMOS Chem-bio Viscosity Sensors based on Dielectric Spectroscopy . In Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2017) ISBN 978-989-758-216-5, pages 142-148. DOI: 10.5220/0006151901420148


in Bibtex Style

@conference{biodevices17,
author={Subhajit Guha and Christian Wenger},
title={Radio Frequency CMOS Chem-bio Viscosity Sensors based on Dielectric Spectroscopy},
booktitle={Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2017)},
year={2017},
pages={142-148},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006151901420148},
isbn={978-989-758-216-5},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2017)
TI - Radio Frequency CMOS Chem-bio Viscosity Sensors based on Dielectric Spectroscopy
SN - 978-989-758-216-5
AU - Guha S.
AU - Wenger C.
PY - 2017
SP - 142
EP - 148
DO - 10.5220/0006151901420148