Laboratory Information Management System for NGS Genomics Labs

Jitao Yang, Shuai Zhu, Guangpeng Xu, Chao Han

2017

Abstract

The goal of genome sequencing is to unravel the ordered sequence of nucleic acids that form the DNA or RNA of a given sample. Genome sequencing lab requires the ability to select and track a large amount of samples through many experimental steps. Therefore, laboratory information management system (LIMS) is needed to provide a way of automating the laboratory experimental procedures and track the samples. LIMSs have been proposed and developed for many years, but still remain difficult for labs to implement successfully. In this paper, we demonstrate our genomic next generation sequencing (NGS) LIMS solution. We developed a web-based LIMS with flexible configuration and customization for NGS laboratories, and can help laboratories track samples and optimize experimental procedures and business workflows. We also describe our solution of integrating LIMS with the existing enterprise business information systems. Finally, we share our experience for the implementation of a successful LIMS.

References

  1. Bath, T. G., Bozdag, S., Afzal, V., and Crowther, D. (2011). Limsportal and Bonsailims: development of a lab information management system for translational medicine. In Source Code Biol Med.
  2. Goodin, B., Poitras, C., and Begin, C. (2016). Mybatis. In http://blog.mybatis.org/.
  3. Grimes, S. M. and Ji, H. P. (2014). Mendelims: a webbased laboratory information management system for clinical genome sequencing. In BMC Bioinformatics.
  4. Hamosh, A., Scott, A. F., Amberger, J. S., Bocchini, C. A., and McKusick, V. A. (2015). Online mendelian inheritance in man (omim), a knowledgebase of human genes and genetic disorders. In Nucleic Acids Research.
  5. Illumina (2016). Basespace Clarity LIMS. http://www.illumina.com/informatics/research/ sequencing-data-analysis-management/genologicslims.html.
  6. Mindspec (2016). Autdb: a Genetic for Autism Spectrum Disorders. http://www.mindspec.org/products/autdb/.
  7. Pinero, J., Queralt-Rosinach, N., Bravo, A., Deu-Pons, J., Bauer-Mehren, A., Baron, M., Sanz, F., and Furlong, L. I. (2015). Disgenet: a discovery platform for the dynamical exploration of human diseases and their genes. In Database (Oxford).
  8. Pivotal (2016). Spring framework. http://projects.spring.io/spring-framework/.
  9. Progeny (2016). Progeny LIMS. http://www.progenygenetics.com/lims/.
  10. SolarGenomics (2016). Solargenomics genome sequencing big data platform. In www.solargenomics.com.
Download


Paper Citation


in Harvard Style

Yang J., Zhu S., Xu G. and Han C. (2017). Laboratory Information Management System for NGS Genomics Labs . In Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 5: HEALTHINF, (BIOSTEC 2017) ISBN 978-989-758-213-4, pages 326-333. DOI: 10.5220/0006149503260333


in Bibtex Style

@conference{healthinf17,
author={Jitao Yang and Shuai Zhu and Guangpeng Xu and Chao Han},
title={Laboratory Information Management System for NGS Genomics Labs},
booktitle={Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 5: HEALTHINF, (BIOSTEC 2017)},
year={2017},
pages={326-333},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006149503260333},
isbn={978-989-758-213-4},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 5: HEALTHINF, (BIOSTEC 2017)
TI - Laboratory Information Management System for NGS Genomics Labs
SN - 978-989-758-213-4
AU - Yang J.
AU - Zhu S.
AU - Xu G.
AU - Han C.
PY - 2017
SP - 326
EP - 333
DO - 10.5220/0006149503260333