Methylene Blue - A Trendy Photosensitizer in Medicine and in Solar-Energy Conversion Systems

Filipa Pires, Margarida Coelho, Paulo A. Ribeiro, Maria Raposo

Abstract

The photosensitizer methylene blue (MB) has been investigated as a deoxyribonucleic acid (DNA) intercalant with the main objective of understanding the chemical/physical processes, which occur when adequate wavelength light is impinging on DNA intercalated with MB. This understanding is crucial for the creation of dynamic phototherapy procedures and for the development of new dye sensitized solar cells. During this work we developed and optimized all the conditions to efficiently produce [MB/DNA] multi-layered films by self-assembly. Our study revealed that pH strongly influences the growth of our multilayer films. Our UV studies revealed that the UV radiation causes damage of DNA through opening of aromatic ring and by breaking the DNA phosphate groups. The FT-IR studies on cast films with [MB/DNA] revealed that the denaturation ratio decreases as the irradiation increases, meaning that MB is an intercalant of DNA chain. This study paves the way to develop new dye sensitized solar cells which employ inexpensive materials and take advantage of the intercalation process in order to adjust the intermolecular arrangement of the donor/acceptor molecules to improve the performance of the device.

References

  1. Decher, G., Schmitt, J. 1992. Fine-tuning of the film thickness of ultrathin multilayer films composed of consecutively alternating layers of anionic and cationic polyelectrolytes. Trends in Colloid and Interface Science VI. Springer.
  2. Gao, S., Cao, R., Yang, C. 2008. Dye-polyoxometalate composite films: Self-assembly, thermal and photochemical properties. Journal of colloid and interface science, 324, 156-166.
  3. Gomes, P. J., Ribeiro, P. A., Shaw, D., Mason, N. J., Raposo, M. 2009. UV degradation of deoxyribonucleic acid. Polymer Degradation and Stability, 94, 2134- 2141.
  4. Impert, O., Katafias, A., Kita, P., Mills, A., PietkiewiczGraczyk, A., Wrzeszcz, G. 2003. Kinetics and mechanism of a fast leuco-Methylene Blue oxidation by copper (II)-halide species in acidic aqueous media. Dalton Transactions, 348-353.
  5. Li, X., Sevilla, M. D., Sanche, L. 2003. Density functional theory studies of electron interaction with DNA: Can zero eV electrons induce strand breaks? Journal of the American Chemical Society, 125, 13668-13669.
  6. Mansuri-Torshizi, H., Ghadimy, S., Akbarzadeh, N. 2001. Synthesis, characterization, DNA binding and cytotoxic studies of platinum (II) and palladium (II) complexes of the 2, 278-bipyridine and an anion of 1, 1- cyclobutanedicarboxylic acid. Chemical and pharmaceutical bulletin, 49, 1517-1520.
  7. Martinez, R., Chacon-Garcia, L. 2005. The search of DNAintercalators as antitumoral drugs: what it worked and what did not work. Current medicinal chemistry, 12, 127-151.
  8. Oliveira Jr, O.N., He, J., Zucolotto, V., Balasubramanian, S., Li, L., Nalwa, H., Kumar, J., Tripathy, S. 2002. Handbook of polyelectrolytes and their applications. American Scientific, New York.
  9. Oliveira Jr, O. N., Raposo, M., Dhanabalan, A. 2001. Langmuir-blodgett and self-assembled polymeric films. Nalwa, HS Handbook of Surfaces and Interfaces of Mateirals, 4, 1-63.
  10. Spencer, W., Sutter J. R. 1979. Kinetic study of the monomer-dimer equilibrium of methylene blue in aqueous solution. Journal of Physical Chemistry, 83, 1573-1576.
  11. Teoule, R. 1987. Radiation-induced DNA damage and its repair. International Journal of Radiation Biology, 51, 573-589.
  12. Wang, Y., Liu, Y., Yang, H., Wang, H., Shen, H., Li, M., Yan, J. 2010. An investigation of DNA-like structured dye-sensitized solar cells. Current Applied Physics, 10, 119-123.
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Paper Citation


in Harvard Style

Pires F., Coelho M., Ribeiro P. and Raposo M. (2016). Methylene Blue - A Trendy Photosensitizer in Medicine and in Solar-Energy Conversion Systems . In Proceedings of the 4th International Conference on Photonics, Optics and Laser Technology - Volume 1: AOMat, (PHOTOPTICS 2016) ISBN 978-989-758-174-8, pages 379-383. DOI: 10.5220/0005843303790383


in Bibtex Style

@conference{aomat16,
author={Filipa Pires and Margarida Coelho and Paulo A. Ribeiro and Maria Raposo},
title={Methylene Blue - A Trendy Photosensitizer in Medicine and in Solar-Energy Conversion Systems},
booktitle={Proceedings of the 4th International Conference on Photonics, Optics and Laser Technology - Volume 1: AOMat, (PHOTOPTICS 2016)},
year={2016},
pages={379-383},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005843303790383},
isbn={978-989-758-174-8},
}


in EndNote Style

TY - CONF
JO - Proceedings of the 4th International Conference on Photonics, Optics and Laser Technology - Volume 1: AOMat, (PHOTOPTICS 2016)
TI - Methylene Blue - A Trendy Photosensitizer in Medicine and in Solar-Energy Conversion Systems
SN - 978-989-758-174-8
AU - Pires F.
AU - Coelho M.
AU - Ribeiro P.
AU - Raposo M.
PY - 2016
SP - 379
EP - 383
DO - 10.5220/0005843303790383